THE EFFECT OF AD, E VITAMIN MIXTURE ON EXPERIMENTALLY INDUCED MEPHOSFOLAN SHORT TERM TOXICITY IN MIC | ||
| Assiut Veterinary Medical Journal | ||
| Article 14, Volume 28.1, Issue 55, October 1992, Pages 158-173 PDF (6.24 M) | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.1992.186641 | ||
| Authors | ||
| H.A. SALEM; S.S. EL-BALLAL; A.Sh. SEDDEK | ||
| Abstract | ||
| In this study, sixty mice were used for induction of short term toxicity with organophosp < /strong>horus comp < /strong>ound 'mephosfolan". They received tenth of the LD so twice weekly for two months. Twenty mice were then treated with AD, E vitamin mixture for further one month. Samples for histopathological and hematological investigations were taken. Histopathological changes after two months toxicity with mep < /strong>hosfolan were mainly degenerative and vascular. They were prominent in the liver, kidney, testis, lung heart, and intestine. Hematological examination revealed a significant decrease in total erythrocytic count, total leukocytic count, hemoglobin concentration, and packed cell volume. A highly significant decrease in true choline estrase activity was observed. Treatmemt with AD, E vitamin mixture for one month resulted only in regeneration of the testis. The other organs as well as the hematological p < /strong>arameters did not resp < /strong>ond. Sp < /strong>ontaneous recpvery was observed in the true chroline estrase activiity without significant differences between vitamin mixture treated and non-treated groups. The significance of these results was discussed. | ||
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