SUBCHRONIC EFFECTS OF INTRAPERITONEAL ADMINISTRATION OF MANGANUS CHLORIDE TO RABBITS | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 14, Volume 3, Issue 1, June 1994, Pages 103-108 PDF (3.53 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1994.186707 | ||
| Author | ||
| Abdel-Aziz Diab* | ||
| Zoology Department, Faculty of Science, Zagazig University, Egypt | ||
| Abstract | ||
| Manganus chloride (2 mg/kg b.wt.) was given every other day intraperitoneally (i.p.) for a period of 5 weeks to mature male rabbits. Rabbits were challenged with Clostridia antisera as a stress factor. The results indicated significant elevation in the levels of ß and y-globulins (P < 0.001), serum ALT and AST activities (P< 0.01) and significant decrease in the levels of a-globulins and urea (SUN) (P < 0.001). The blood picture was not significantly changed except for eosinophils and monocytes counts which showed a marked increase and decrease (P <0.001) respectively. Whereas, a moderate increase (P < 0.05) was recorded in PO2, O2 SAT% and O2-CT% of the blood. This study represents the hazardous effect of prolonged exposure to manganus chloide in both histotoxic anoxia and liver dysfunction. | ||
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