OPTIMIZATION AND MECHANISTIC STUDIES OF FACILE DEBROMINATION OF VINYL BROMIDES WITH VICINAL SUBSTITUTED AMINO GROUP RESIDUES
Al-Sabbagh, O., El-Bermawy, M., EI-Sadek, M., Al-Ashmawi, M. (1994). OPTIMIZATION AND MECHANISTIC STUDIES OF FACILE DEBROMINATION OF VINYL BROMIDES WITH VICINAL SUBSTITUTED AMINO GROUP RESIDUES. EKB Journal Management System, 3(1), 131-135. doi: 10.21608/zjps.1994.186723
Osama Al-Sabbagh; Mohamed El-Bermawy; Mohamed EI-Sadek; Mohamed Al-Ashmawi. "OPTIMIZATION AND MECHANISTIC STUDIES OF FACILE DEBROMINATION OF VINYL BROMIDES WITH VICINAL SUBSTITUTED AMINO GROUP RESIDUES". EKB Journal Management System, 3, 1, 1994, 131-135. doi: 10.21608/zjps.1994.186723
Al-Sabbagh, O., El-Bermawy, M., EI-Sadek, M., Al-Ashmawi, M. (1994). 'OPTIMIZATION AND MECHANISTIC STUDIES OF FACILE DEBROMINATION OF VINYL BROMIDES WITH VICINAL SUBSTITUTED AMINO GROUP RESIDUES', EKB Journal Management System, 3(1), pp. 131-135. doi: 10.21608/zjps.1994.186723
Al-Sabbagh, O., El-Bermawy, M., EI-Sadek, M., Al-Ashmawi, M. OPTIMIZATION AND MECHANISTIC STUDIES OF FACILE DEBROMINATION OF VINYL BROMIDES WITH VICINAL SUBSTITUTED AMINO GROUP RESIDUES. EKB Journal Management System, 1994; 3(1): 131-135. doi: 10.21608/zjps.1994.186723

OPTIMIZATION AND MECHANISTIC STUDIES OF FACILE DEBROMINATION OF VINYL BROMIDES WITH VICINAL SUBSTITUTED AMINO GROUP RESIDUES

Zagazig Journal of Pharmaceutical Sciences
Article 18, Volume 3, Issue 1, June 1994, Pages 131-135    PDF (2.69 M)
Document Type: Original Article
DOI: 10.21608/zjps.1994.186723
Authors
Osama Al-Sabbagh* 1; Mohamed El-Bermawy2; Mohamed EI-Sadek* 1; Mohamed Al-Ashmawi2
1Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt
2Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
Abstract
Debromination of α- bromoketones can be conducted easily. However, debromination of vinyl bromides is extremely difficult and requires vigorous conditions. This study describes the optimum conditions for the facile debromination of vinyl bromides. A plausible mechanism for the easy debromination is proposed. Also, attempted application of ring contraction of 2-bromocyclohexanediones using Favorskii conditions was unsuccessful.
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