HIV-1 RT-Associated RNase H review | ||
| Archives of Pharmaceutical Sciences Ain Shams University | ||
| Article 3, Volume 2, Issue 1, January 2018, Pages 22-30 PDF (626.18 K) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/aps.2018.18731 | ||
| Authors | ||
| Madonna M. A. Mitry* ; Nermin S. Abdou; Rabah A. T. Serya | ||
| Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt | ||
| Abstract | ||
| HIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H). The RNase H is function to cleave RNA strand in RNA/DNA hybrid intermediate in the reverse transcription process. Currently, successful inhibitors target the polymerase function of HIV-RT. RNase H evolves to be a promising target for anti-HIV drug research. This review describes the compounds reported as HIV-1 RNase H inhibitors. | ||
| Keywords | ||
| HIV-1; ribonuclease H; reverse transcriptase; tropolone; hydrazone | ||
|
Statistics Article View: 577 PDF Download: 582 |
||
