DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND
El-Bermawy, M. (1993). DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND. EKB Journal Management System, 2(2), 103-110. doi: 10.21608/zjps.1993.187356
Mohamed El-Bermawy. "DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND". EKB Journal Management System, 2, 2, 1993, 103-110. doi: 10.21608/zjps.1993.187356
El-Bermawy, M. (1993). 'DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND', EKB Journal Management System, 2(2), pp. 103-110. doi: 10.21608/zjps.1993.187356
El-Bermawy, M. DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND. EKB Journal Management System, 1993; 2(2): 103-110. doi: 10.21608/zjps.1993.187356

DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND

Zagazig Journal of Pharmaceutical Sciences
Article 9, Volume 2, Issue 2, December 1993, Pages 103-110    PDF (3.61 M)
Document Type: Original Article
DOI: 10.21608/zjps.1993.187356
Author
Mohamed El-Bermawy*
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
Abstract
Serotonin (5-HT) 1A receptors have been shown to have physiological, biochemical pharmacological and clinical values. The piperazino derivative 1 was rationally designed as a bulky, lipophilic N4-substituted arylpiperazine. Radioligand binding assay of 1 at 5-HT1A receptors indicates that it binds at these receptors with higher affinity than the famous 5-HT1A, ligand, buspirone (Ki = 15 nM). Buspirone is currently used to treat anxiety.
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