PHARMACOLOGICAL EVALUATION OF TOLTRAZURIL WITH SPECIAL REFERENCE TO ITS ADVERSE EFFECTS
Abd El Aziz, M., Abdel-Motal, S., Khairy, M., El-Gammal, A., Shams, G., Fouad, A., Mankarios, E. (1993). PHARMACOLOGICAL EVALUATION OF TOLTRAZURIL WITH SPECIAL REFERENCE TO ITS ADVERSE EFFECTS. EKB Journal Management System, 2(2), 117-129. doi: 10.21608/zjps.1993.187359
Mostafa Abd El Aziz; Sabri Abdel-Motal; Mohamed Khairy; Ashour El-Gammal; Gamal Shams; Abdel-Alem Fouad; Elene Mankarios. "PHARMACOLOGICAL EVALUATION OF TOLTRAZURIL WITH SPECIAL REFERENCE TO ITS ADVERSE EFFECTS". EKB Journal Management System, 2, 2, 1993, 117-129. doi: 10.21608/zjps.1993.187359
Abd El Aziz, M., Abdel-Motal, S., Khairy, M., El-Gammal, A., Shams, G., Fouad, A., Mankarios, E. (1993). 'PHARMACOLOGICAL EVALUATION OF TOLTRAZURIL WITH SPECIAL REFERENCE TO ITS ADVERSE EFFECTS', EKB Journal Management System, 2(2), pp. 117-129. doi: 10.21608/zjps.1993.187359
Abd El Aziz, M., Abdel-Motal, S., Khairy, M., El-Gammal, A., Shams, G., Fouad, A., Mankarios, E. PHARMACOLOGICAL EVALUATION OF TOLTRAZURIL WITH SPECIAL REFERENCE TO ITS ADVERSE EFFECTS. EKB Journal Management System, 1993; 2(2): 117-129. doi: 10.21608/zjps.1993.187359

PHARMACOLOGICAL EVALUATION OF TOLTRAZURIL WITH SPECIAL REFERENCE TO ITS ADVERSE EFFECTS

Zagazig Journal of Pharmaceutical Sciences
Article 11, Volume 2, Issue 2, December 1993, Pages 117-129    PDF (5.41 M)
Document Type: Original Article
DOI: 10.21608/zjps.1993.187359
Authors
Mostafa Abd El Aziz* 1; Sabri Abdel-Motal2; Mohamed Khairy3; Ashour El-Gammal2; Gamal Shams4; Abdel-Alem Fouad2; Elene Mankarios2
1Department. of pharmacology, Faculty of Veterinary Medicine, Zagazig University.
2Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt.
3Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt.
4Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt
Abstract
Toltrazuril which is a novel anticoccidial agent elicit an inhibitory effect on the isolated smooth muscles of both intestine and oviduct of chicken. It was proved that its effect is due to an antihistamine-like effect. Toltrazuril exerted a negative inotropic effect on isolated chicken's heart with a decrease in coronary outflow. The drug induced hypotension with increased respiratory rate. Moreover, oral adminstration of toltrazuril produced a significant increase in serum GOT, glucose, creatinine and uric acid. The drug elicited a significant decrease in serum GPT, total protein and cholesterol levels. Histopathological findings were discussed.
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