SPECTRODENSITOMETRIC DETERMINATION OF CERTAIN DIUTRETIC MIXTURES | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 13, Volume 2, Issue 2, December 1993, Pages 139-149 PDF (4.63 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1993.187361 | ||
| Authors | ||
| Mohamed El-Sadek* 1; Abdalla El-Shanawani2; Sobhy El-Adl3 | ||
| 1Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt | ||
| 2Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. | ||
| 3Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt | ||
| Abstract | ||
| A simple and direct spectrodensitometric method has been developed for the qualitative and quantitative determination of three pairs of diuretic mixtures: i- spironolactone with hydrochlorothiazide, ii- captopril with hydrochlorothiazide and ii- spironolactone with furosemide p-Chloroacetanilide was used as internal standard in quantitative determination. The method was applied for the determination of these drugs in different pharmaceutical dosage forms: Aldactazide, Capozide tablets and Fructone capsules. The results indicated high accuracy and reproducibility. | ||
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