SYNTHESIS OF CERTAIN SUBSTITUTED 7-CHLORO-4- QUINAZOLONES OF PHARMACEUTICAL INTEREST
Al-Ashmawi, M., Shabaan, M., Omar, R. (1993). SYNTHESIS OF CERTAIN SUBSTITUTED 7-CHLORO-4- QUINAZOLONES OF PHARMACEUTICAL INTEREST. EKB Journal Management System, 2(2), 158-168. doi: 10.21608/zjps.1993.187364
Mohamed Al-Ashmawi; Mohamed Shabaan; Refaat Omar. "SYNTHESIS OF CERTAIN SUBSTITUTED 7-CHLORO-4- QUINAZOLONES OF PHARMACEUTICAL INTEREST". EKB Journal Management System, 2, 2, 1993, 158-168. doi: 10.21608/zjps.1993.187364
Al-Ashmawi, M., Shabaan, M., Omar, R. (1993). 'SYNTHESIS OF CERTAIN SUBSTITUTED 7-CHLORO-4- QUINAZOLONES OF PHARMACEUTICAL INTEREST', EKB Journal Management System, 2(2), pp. 158-168. doi: 10.21608/zjps.1993.187364
Al-Ashmawi, M., Shabaan, M., Omar, R. SYNTHESIS OF CERTAIN SUBSTITUTED 7-CHLORO-4- QUINAZOLONES OF PHARMACEUTICAL INTEREST. EKB Journal Management System, 1993; 2(2): 158-168. doi: 10.21608/zjps.1993.187364

SYNTHESIS OF CERTAIN SUBSTITUTED 7-CHLORO-4- QUINAZOLONES OF PHARMACEUTICAL INTEREST

Zagazig Journal of Pharmaceutical Sciences
Article 15, Volume 2, Issue 2, December 1993, Pages 158-168    PDF (4.49 M)
Document Type: Original Article
DOI: 10.21608/zjps.1993.187364
Authors
Mohamed Al-Ashmawi* 1; Mohamed Shabaan2; Refaat Omar2
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2Department of Organic Chemistry, Faculty of Pharmacy, Cairo University
Abstract
The synthesis of some N-(7-chioro-3-phenyl-4 (3H)-quinazolinon-2-ylmercaptoacetyi) hydrazones is described. Reacting 7-chloro-3-phenyl-4-quinazolinone-2-thione with ethyl chloroacetate yielded two isomeric esters. Condensation of these esters with hydrazine hydrate under different reaction conditions afforded the expected hydrazides in addition to some sulphur free products.
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