Assessment of DNA Damage on Adult Albino Rats Induced by Dermal Exposure to P-Phenylenediamine (PPD) | ||
| Ain Shams Journal of Forensic Medicine and Clinical Toxicology | ||
| Article 15, Volume 23, Issue 2, July 2014, Pages 173-181 PDF (1.03 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajfm.2014.18763 | ||
| Authors | ||
| Ahmed AlSeigini; Amany ElSayed; Hend ElHelaly; Eman Abdelhakim | ||
| Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt. | ||
| Abstract | ||
| Hair dyes are widely used as cosmetic agents to color the grey hair around the world. P-phenylenediamine (PPD) induced genotoxicity due to dermal application was investigated in this study. 90 rats conducted this study and were classified into main 4 groups. Negative control group, positive control group. In-addition, two toxicity groups; short term toxicity group and long term toxicity group. Both toxicity groups were further subdivided according to PPD dose into 10 and 15 mg/kg subgroups. The results showed that repeated dermal exposure to PPD induced significant DNA damage in peripheral blood lymphocytes in dose and time dependent manner. | ||
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