Convenient Synthesis and Molecular Docking of Novel Pyrido [2,3- d ]pyrimidines as Potent Antimicrobial Candidates.
sarhan, A., soliman, H., Saleh, A., Nofal, Z. (2022). Convenient Synthesis and Molecular Docking of Novel Pyrido [2,3- d ]pyrimidines as Potent Antimicrobial Candidates.. EKB Journal Management System, 65(2), 399-411. doi: 10.21608/ejchem.2021.87454.4223
Alaadin sarhan; hanaa M. soliman; Abdulrahman M. Saleh; Zinab M. Nofal. "Convenient Synthesis and Molecular Docking of Novel Pyrido [2,3- d ]pyrimidines as Potent Antimicrobial Candidates.". EKB Journal Management System, 65, 2, 2022, 399-411. doi: 10.21608/ejchem.2021.87454.4223
sarhan, A., soliman, H., Saleh, A., Nofal, Z. (2022). 'Convenient Synthesis and Molecular Docking of Novel Pyrido [2,3- d ]pyrimidines as Potent Antimicrobial Candidates.', EKB Journal Management System, 65(2), pp. 399-411. doi: 10.21608/ejchem.2021.87454.4223
sarhan, A., soliman, H., Saleh, A., Nofal, Z. Convenient Synthesis and Molecular Docking of Novel Pyrido [2,3- d ]pyrimidines as Potent Antimicrobial Candidates.. EKB Journal Management System, 2022; 65(2): 399-411. doi: 10.21608/ejchem.2021.87454.4223

Convenient Synthesis and Molecular Docking of Novel Pyrido [2,3- d ]pyrimidines as Potent Antimicrobial Candidates.

Egyptian Journal of Chemistry
Article 43, Volume 65, Issue 2, February 2022, Page 399-411  XML PDF (986.38 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.87454.4223
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Authors
Alaadin sarhan email orcid 1; hanaa M. solimanorcid 2; Abdulrahman M. Salehorcid 3; Zinab M. Nofal4
1Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Center, 33 El Behouth St, Dokki-Giza, 12622-Egypt.
22Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt, 12622.
33 Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys) Al-Azhar University , Cairo-Egypt
4Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Center, 33 El Behouth St, Dokki-Giza, 12622-Egypt
Abstract
New 3-(3,4-dimethoxyphenyl)-1-(thiophene-2-yl)prop-2-en-1-one has been designed as a starting compound to synthesis a novel series of substituted pyrido[2,3-d]pyrimidine system incorporated to different Schiff's bases and enamine derivatives as potent antimicrobial compounds. Novel synthesized compounds were evaluated for their in-vitro antimicrobial potency against different gram-positive and gram-negative bacteria, where they reveal high effectuality at low concentration compared to Trimethoprim. Docking studies and structure-activity relationship declared that new pyrido [2,3-d] pyrimidines completely occupied the active pocket of Biotin Carboxylase of both bacterial types and fungal strains acting as selective Fatty Acid Synthesase type II inhibitors.
Keywords
Pyrido [2; 3-d] pyrimidine; Antimicrobial; Biotin Carboxylase; Molecular Docking
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