SYNTHESIS AND ANTIBACTERIAL EVALUATION OF CERTAIN 1,2,4- TRIAZOLE AND THIAZOLID INONE DERIVATIVES | ||
Zagazig Journal of Pharmaceutical Sciences | ||
Article 11, Volume 2, Issue 1, June 1993, Pages 108-119 PDF (4.52 M) | ||
Document Type: Original Article | ||
DOI: 10.21608/zjps.1993.188994 | ||
Authors | ||
Awatef Farag* 1; Safinaz Abbas1; Anwar Mikhael2; Mona Abdel Messeh2 | ||
1Pharmaceutical Chemistry Department, faculty of Pharmacy, Cairo University, Cairo, Egypt | ||
2BACTERIOLOGY DEPARTMENT, FACULTY OF MEDICINE, CAIRO UNIVERSITY. | ||
Abstract | ||
The synthesis of certain 3 - (4- chloro - 3,5 - đimethyl - phenoxy ) methyl 4-alkyl or aryl -5 mercapto - 1,2,4 - triazoles ( 5a - e) is described. The preparation of these triazoles was achieved by the cyclization of the corresponding thiosemicarbazides (Af- i) using piperidine in refluxing ethanol. Also , series of thioethers (6a,b) and (7a-g) were obtained by reacting (5) with different halo- compounds .The thiaz olidinone derivatives (8 a - d ) were prepared by reacting (4f - j) with ethyl bromoacetate .The new compounds were proved by elemental analysis, ir and 1H- nmr. The antibacterial activity was carried out for eight representative compounds . | ||
Statistics Article View: 107 PDF Download: 79 |