SYNTHESIS OF NEW CONDENSED PYRIMIDINES: I
Ebeid, M., Lashine, S., El-Shanawani, A., Abou-Kull, M., Abou Taleb, N. (1992). SYNTHESIS OF NEW CONDENSED PYRIMIDINES: I. EKB Journal Management System, 1(1), 43-54. doi: 10.21608/zjps.1992.189019
Mohamed Ebeid; Sayed Lashine; Abdalla El-Shanawani; Mansour Abou-Kull; N. Abou Taleb. "SYNTHESIS OF NEW CONDENSED PYRIMIDINES: I". EKB Journal Management System, 1, 1, 1992, 43-54. doi: 10.21608/zjps.1992.189019
Ebeid, M., Lashine, S., El-Shanawani, A., Abou-Kull, M., Abou Taleb, N. (1992). 'SYNTHESIS OF NEW CONDENSED PYRIMIDINES: I', EKB Journal Management System, 1(1), pp. 43-54. doi: 10.21608/zjps.1992.189019
Ebeid, M., Lashine, S., El-Shanawani, A., Abou-Kull, M., Abou Taleb, N. SYNTHESIS OF NEW CONDENSED PYRIMIDINES: I. EKB Journal Management System, 1992; 1(1): 43-54. doi: 10.21608/zjps.1992.189019

SYNTHESIS OF NEW CONDENSED PYRIMIDINES: I

Zagazig Journal of Pharmaceutical Sciences
Article 5, Volume 1, Issue 1, June 1992, Pages 43-54    PDF (5.02 M)
Document Type: Original Article
DOI: 10.21608/zjps.1992.189019
Authors
Mohamed Ebeid* 1; Sayed Lashine2; Abdalla El-Shanawani3; Mansour Abou-Kull4; N. Abou Taleb5
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt
3Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
4Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt
5Pharmaceutical Chemistry Department, Faculty of Pharmacy, university of Cairo, Egypt .
Abstract
2-Dicyanomethylidinoindoline (I) obtained from lactime ether of  oxindole and malononitrile, when added to various isocyanates or isothiocyanates afforded 2-alkye-3-imino-1-oxo or thioxo-1,2,3,4,4a,5-hexahydro-pyrimido1,6-alindole-4-carbonitrile. The corresponding enaminonitriles were obtained by reduction with sodium borohydride. Álkylation and hydrolysis of the prepared compounds are also described .
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