ASSESSMENT OF SERUM LEVELS OF INTERLEUKIN-18 AND IMMUNOGLOBULIN E IN PATIENTS WITH CHRONIC SPONATNEOUS URTICARIA AND THEIR RELATION TO SEVERITY OF THE DISEASE | ||||
| ALEXMED ePosters | ||||
| Article 194, Volume 3, Issue 4, December 2021, Page 25-26 | ||||
| Document Type: Preliminary preprint short reports of original research | ||||
| DOI: 10.21608/alexpo.2021.91041.1249 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Marwa Youssef Mohamed 
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| Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University | ||||
| Abstract | ||||
| Chronic spontaneous urticaria is defined by recurrent episodes occurring at least twice a week for ≥ 6 weeks without inducible causes. Females are more commonly affected than males. The etiology of CU is heterogeneous. CU has a significant impact on quality of life. CU is a common skin condition that affects up to 5% of the general population. IgE plays an essential role in type I hypersensitivity, which manifests various allergic diseases such as allergic asthma, allergic rhinitis, food allergy, some types of chronic urticaria and atopic dermatitis. IgE-mediated autoimmunity or autoallergy against several autoallergens, including thyroid peroxidase, double stranded DNA, IL-24, thyroglobulin and tissue factor, is thought to play a major role in the pathogenesis of CSU. Interleukin (IL)-18 is a pleotropic cytokine that provides an important link between innate and adaptive immune responses and it can enhance both.It can activate T cells and induce either T-helper (Th) 1 or Th2 responses, depending on the cytokine environment. It has been suggested that IL-18 may play an important role either in autoimmune disorders, characterized by a predominant Th1 response, or in allergic diseases, characterized by a Th2 response. | ||||
| Keywords | ||||
| IMMUNOGLOBULIN E; INTERLEUKIN-18; CHRONIC SPONATNEOUS URTICARIA | ||||
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