Insulin Resistance in Diabetic CKD: A Hospital-Based Study in Egypt | ||
| Suez Canal University Medical Journal | ||
| Article 2, Volume 24, Issue 2, October 2021, Pages 104-108 PDF (277.23 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2021.192013 | ||
| Authors | ||
| Heba A Attea* 1; Alaa El Din S Abd El Hamid2; Mohammed M Keshawy1; Mohamed S Khedr1 | ||
| 1Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt | ||
| 2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt | ||
| Abstract | ||
| Background:The presence of insulin resistance (IR) and compensatory hyper-insulinemia is strongly associated with chronic kidney disease (CKD) stages and constellates with other abnormalities such as obesity, hypertension, and dyslipidemia. CKD is associated with significant morbidity and mortality. A variety of factors, including inflammation, oxidative stress and metabolic acidosis are associated with insulin resistance. Aim: To identify the relationship between insulin resistance and diabetic kidney disease (DKD). Patients and Methods: The study was performed as a cross-sectional study including 84 patients with type 2 diabetes mellitus admitted in Suez Canal University Hospitals. Results: In diabetics with normal kidney function 28.6% of had IR, while 78.6% of diabetic patients with late DKD had IR according to HOMA- IR with significant relationship between the progress of DKD and IR(p value ≤ 0.05).Conclusion: The presence of insulin resistance is strongly associated with DKD and its progress. | ||
| Keywords | ||
| Diabetes; dyslipidemia; kidney | ||
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