Cytotoxic and Antileishmanial Activities of the Red Sea Soft Coral Sarcophyton glaucum Extract and Some of Its Isolates
El-Ayouty, M., Abdelhameed, R., Habib, E., Hassanean, H., Ahmed, S. (2021). Cytotoxic and Antileishmanial Activities of the Red Sea Soft Coral Sarcophyton glaucum Extract and Some of Its Isolates. EKB Journal Management System, 5(Pharmacognosy-Microbiology), 115-120. doi: 10.21608/rpbs.2021.90767.1111
Mayada Mohamed El-Ayouty; Reda Foaad Abdelhameed; Eman Sanad Habib; Hashim Hassanean; Safwat Ahmed. "Cytotoxic and Antileishmanial Activities of the Red Sea Soft Coral Sarcophyton glaucum Extract and Some of Its Isolates". EKB Journal Management System, 5, Pharmacognosy-Microbiology, 2021, 115-120. doi: 10.21608/rpbs.2021.90767.1111
El-Ayouty, M., Abdelhameed, R., Habib, E., Hassanean, H., Ahmed, S. (2021). 'Cytotoxic and Antileishmanial Activities of the Red Sea Soft Coral Sarcophyton glaucum Extract and Some of Its Isolates', EKB Journal Management System, 5(Pharmacognosy-Microbiology), pp. 115-120. doi: 10.21608/rpbs.2021.90767.1111
El-Ayouty, M., Abdelhameed, R., Habib, E., Hassanean, H., Ahmed, S. Cytotoxic and Antileishmanial Activities of the Red Sea Soft Coral Sarcophyton glaucum Extract and Some of Its Isolates. EKB Journal Management System, 2021; 5(Pharmacognosy-Microbiology): 115-120. doi: 10.21608/rpbs.2021.90767.1111

Cytotoxic and Antileishmanial Activities of the Red Sea Soft Coral Sarcophyton glaucum Extract and Some of Its Isolates

Records of Pharmaceutical and Biomedical Sciences
Article 12, Volume 5, Pharmacognosy-Microbiology - Serial Number 2, January 2021, Pages 115-120    PDF (293.87 K)
Document Type: Original Article
DOI: 10.21608/rpbs.2021.90767.1111
Authors
Mayada Mohamed El-Ayouty1; Reda Foaad Abdelhameed2; Eman Sanad Habib3; Hashim Hassanean4; Safwat Ahmed* 4
1Department of Pharmacognosy, Faculty of Pharmacy, Sinai University, El-Arish, Egypt
2Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
3Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, 41522, Ismailia, Egypt
4Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
Abstract
Truthfully, natural products have been the principal productive source of advancing new drugs. The broad aim of this work was to conduct a phytochemical and biological study of the Red Sea soft coral Sarcophyton glaucum, Family: Alcyoniidae collected from Red Sea at the Egyptian coasts. The phytochemical investigation from the soft coral S. glaucum led to the isolation of ten compounds including: palmitic acid (1), stearic acid (2), (24S)-24-methyl cholesterol (3), batyl alcohol (4), heptadecanoic acid pentadecyl ester (5), sarcophine (6), (+)-7α, 8β-dihydroxydeepoxysarcophine (7), uracil (8), thymine (9) and a ceramide (10). As cancer is one of the most hazardous factors threatening the human life, in this study the potential in-vitro cytotoxicity of the soft coral S. glaucum extract and three marine isolates were measured against HepG2 and MCF7 using Sulphorhodamine-B (SRB) assay and all of the tested samples showed a good cytotoxic activities against both hepatic and breast cancer. The extract of S. glaucum was tested also against the protozoan parasite Leishmania donovani, using pentamidine and amphotericin B as controls and showed antileishmanial activity.
Keywords
Sarcophyton glaucum; cytotoxic activity; antileishmanial activity
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