Synthesis and Cytotoxic Activity of New Substituted Pyrazolo[3,4-b]pyridine Derivatives and Their Acyclic Nucleoside Analogs | ||
| Egyptian Journal of Chemistry | ||
| Article 15, Volume 65, Issue 3, March 2022, Pages 161-169 PDF (600.96 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.90009.4302 | ||
| Authors | ||
| Mohamed Abdallah Hawata* 1; Farag El-Essawy2; Wael A. El-Sayed3; Mohamed El-Bayaa4 | ||
| 1Faculty of science menoufia university shebien ElKoom Egypt | ||
| 2Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt. | ||
| 3Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt | ||
| 4Photochemistry Department, National Research Centre | ||
| Abstract | ||
| As an important strategy, including incorporation of more than active core in one molecule, for finding potent candidates against cancer cells, a number of functionalized pyrazolopyridin derivatives linked to oxadiazole, dioxolane, acyclic sugar and fluorene ring systems, were synthesized through heterocyclization reactions. The derived sugar hydrazone and the corresponding acyclic C-nucleoside analog in addition to acyclic N-nucleoside were also prepared. The behavior of the afforded compounds as possible cytotoxic agents against human HTC116 and MCF7 cancer cells was investigated and the results showed that compounds 11-13 showed the highest activities against the two cancer cells. Other compounds revealed a type of selectivity toward one cancer cell while the activity was relatively lost against the other cancer cell line. | ||
| Keywords | ||
| pyrazolopyridin; sugar; hydrazone; oxadiazole; acyclic nucleoside; anticancer | ||
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