Alleviation of imidacloprid-induced oxidative stress and immune damage by Spirulina platensis in broiler chickens
Abotaleb, A., AboSalem, M., Elshewy, E., Abdeen, A. (2021). Alleviation of imidacloprid-induced oxidative stress and immune damage by Spirulina platensis in broiler chickens. EKB Journal Management System, 40(2), 144-148. doi: 10.21608/bvmj.2021.72833.1397
Amira Abotaleb; Mohamed AboSalem; Elham Abdelmoneim Elshewy; Ahmed Abdeen. "Alleviation of imidacloprid-induced oxidative stress and immune damage by Spirulina platensis in broiler chickens". EKB Journal Management System, 40, 2, 2021, 144-148. doi: 10.21608/bvmj.2021.72833.1397
Abotaleb, A., AboSalem, M., Elshewy, E., Abdeen, A. (2021). 'Alleviation of imidacloprid-induced oxidative stress and immune damage by Spirulina platensis in broiler chickens', EKB Journal Management System, 40(2), pp. 144-148. doi: 10.21608/bvmj.2021.72833.1397
Abotaleb, A., AboSalem, M., Elshewy, E., Abdeen, A. Alleviation of imidacloprid-induced oxidative stress and immune damage by Spirulina platensis in broiler chickens. EKB Journal Management System, 2021; 40(2): 144-148. doi: 10.21608/bvmj.2021.72833.1397

Alleviation of imidacloprid-induced oxidative stress and immune damage by Spirulina platensis in broiler chickens

Benha Veterinary Medical Journal
Article 29, Volume 40, Issue 2, July 2021, Pages 144-148    PDF (516.61 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2021.72833.1397
Authors
Amira Abotaleb* 1; Mohamed AboSalem2; Elham Abdelmoneim Elshewy3; Ahmed Abdeen3
1forensic medicine and toxicology, faculty of veterinary medicine, benha university
2forensic medicine and toxicology,faculty of veterinary medicine,benha university
3forensic medicine and toxicology,faculty of veterinary medicine, benha university
Abstract
Imidacloprid (IM) is a neonicotinoid insecticide being used extensively for crop protection and pet flea control programmes. However, IM is also a strong environmental toxicant for both animals and humans. As a result, the present study aimed to assess the ameliorative efficacy of Spirulina platensis (SP) aganist IM-induced oxidative stress and immune damage in broiler chickens. Chicks divided randomly into six equal groups (17 each). Group I administered filtered water orally for 4 weeks. Group II administered IM 10 mg/kg b.wt orally daily for 4 weeks. Group III given Spirulina 5 g/kg of diet for 4 weeks. Group IV received IM plus Spirulina for 4 weeks. Group V received IM for 2 weeks, followed by Spirulina for another 2 weeks. Group VI received spirulina for 2 weeks, followed by IM for another 2 weeks. Results revealed that IM significantly decreased body weight while increased feed conversion rate (FCR), total leukocytic count (TLC) and lymphocyte percent. Serum showed a decrease in haemagglutination inhibition (HI) antibody titer against newcastle disease (ND) vaccine. Antioxidant enzymes such as reduced glutathione (GSH) and catalase (CAT) significantly decreased; while malondialdehyde (MDA) increased in bursa of Fabricius tissue accompanied with histological changes. Administration of Spirulina in combination, before and after treatment with IM significantly ameliorated the IM-induced oxidative stress and immune damage due to its antioxidant properties.
Keywords
Imidacloprid; Spirulina platensis; Oxidative stress; Immunotoxicity
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