Evaluation of the role of vitamin D in chronic kidney disease, dialysis patients and its Impact on cardio vascular mortality
Ibrahim, M., Okasha, K., Mahmoud, A., Gamal, A., Mansour, A. (2021). Evaluation of the role of vitamin D in chronic kidney disease, dialysis patients and its Impact on cardio vascular mortality. EKB Journal Management System, 38(3), 937-950. doi: 10.21608/bmfj.2021.71835.1407
Mohamed E. Ibrahim; Kamal M Okasha; Ashraf T Mahmoud; Amany Gamal; Ahmed E Mansour. "Evaluation of the role of vitamin D in chronic kidney disease, dialysis patients and its Impact on cardio vascular mortality". EKB Journal Management System, 38, 3, 2021, 937-950. doi: 10.21608/bmfj.2021.71835.1407
Ibrahim, M., Okasha, K., Mahmoud, A., Gamal, A., Mansour, A. (2021). 'Evaluation of the role of vitamin D in chronic kidney disease, dialysis patients and its Impact on cardio vascular mortality', EKB Journal Management System, 38(3), pp. 937-950. doi: 10.21608/bmfj.2021.71835.1407
Ibrahim, M., Okasha, K., Mahmoud, A., Gamal, A., Mansour, A. Evaluation of the role of vitamin D in chronic kidney disease, dialysis patients and its Impact on cardio vascular mortality. EKB Journal Management System, 2021; 38(3): 937-950. doi: 10.21608/bmfj.2021.71835.1407

Evaluation of the role of vitamin D in chronic kidney disease, dialysis patients and its Impact on cardio vascular mortality

Benha Medical Journal
Article 180, Volume 38, Issue 3, November and December 2021, Pages 937-950    PDF (750.25 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2021.71835.1407
Authors
Mohamed E. Ibrahim1; Kamal M Okasha2; Ashraf T Mahmoud3; Amany Gamal* 4; Ahmed E Mansour1
1Internal Medicine and Nephrology, Faculty of Medicine, Banha University
2Internal medicine and Nephrology, Faculty of Medicine, Tanta University
3Internal Medicine, Dean of Damietta Faculty of Medicine, Damietta University
4MBBCH
Abstract
Background: Patients with chronic kidney disease are frequently suffering from the deficiency of 1,25-dihydroxyvitamin D3 (calcitriol). This study aimed to evaluate the role of vitamin D deficiency in chronic kidney disease patients, with and without dialysis and its impact on cardio vascular morbidity If fetal or not fatal. Methods: The study was carried on 100 cases and divided into three groups: Group A: 25 healthy cases (control group), Group B: 50 patients with known chronic kidney disease under conservative treatment and Group C: 25 patients with chronic kidney diseases under hemodialysis. Results: Group A (control) included 10 males and 15 females, their mean age was 42.56±3.1 years, group B (CKD) included 27 males and 23 females, their mean age was 41.6±2.5 years, group C (CKD+ dialysis) included 12 males and 13 females, their mean age was 43.3±2 years. Vitamin D was statistically higher in group A (36±7.4) than group B (17±2.5), and group C (11.4±1.5), p < 0.001. And between group B&C, p < 0.001. The group with normal ECG had statistically higher levels of vitamin D (mean= 24.5±10.8) compared to the group with abnormal ECG (mean= 13.9±4.1), p < 0.001. Eight patients of group B (16%) died during the study period, On comparison between alive and died patients regarding the clinical data; vit D was statistically higher in alive group, p=0.04. Conclusion; High prevalence of vit D deficiency in CKD patients, and showed a significant association between 25‐OH vitamin D levels and major ECG abnormalities and Echo.
Keywords
vitamin D; kidney; dialysis; cardiovascular; mortality
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