Evaluation of the Efficacy of 1%Alendronate Gel as Adjunctive Treatment in Class II Furcation Defects (Clinical, Radiographic and Biochemical Study) | ||
| Al-Azhar Assiut Dental Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 11 September 2021 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aadj.2021.44852.1051 | ||
| Authors | ||
| Dalia Hamed Shehab* 1; Mohamed Fouad Edrees2; Ahmed Hussien Gaber3 | ||
| 1Periodontology , oral medicine,oral radiology and diagnosis , Faculty of dentistry ,azhar university (Assiut branch) , Assiut | ||
| 2Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology Department, Faculty of Dentistry, Al-Azhar University (Assiut Branch) | ||
| 3Oral Pathology, Faculty of Dentistry, Al-Azhar University (Assiut Branch) | ||
| Abstract | ||
| Aim: This study was designed to evaluate the efficacy of 1% alendronate gel as an adjunctive therapy to scaling and root planing in the treatment of class II furcation defects. Patients and method: Twenty-six patients with mandibular class II furcation involvement were selected from the out-patient clinic, Oral Medicine and Periodontology Department, Faculty of Dentistry, Al-Azhar University, Assiut Branch. They were divided into two equal groups. Group I received conventional periodontal therapy alone, while group II received conventional periodontal therapy combined with intra-furcal application of 1% alendronate gel as adjunctive therapy. All patients were evaluated clinically, radiographically as well as for RANKL level in GCF at base line, 3 and 6 months. Results: Both groups showed a high significant difference between base line and 6 months in all clinical parameters (PI, GI, VPD, CAL and HPD), radiographic parameters (bone density) and RANKL level in GCF. There was a statistical significant difference to group II when compared to group I in VPD and HPD at 6 months only and in CAL, bone density and RANKL level at 3 and 6 months. Conclusion: intra-furcal application of 1%Alendronate gel seemed an attractive effect as adjunctive therapy in improving the clinical, radiographic parameters and RANKL level in GCF in the treatment of class II furcation defects. | ||
| Keywords | ||
| Alendronate; class II furcation; adjunctive treatment | ||
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