New and Facile Synthesis of Pyrimidine, Coumarine, Pyrimido[1,6-a]Pyrimidine, 1,2,4-Triazine and Pyrimido[4,5-c] Pyridazine Derivatives
El-Taweel, F., Said, S., Ramadan, S., Elagamey, A. (2013). New and Facile Synthesis of Pyrimidine, Coumarine, Pyrimido[1,6-a]Pyrimidine, 1,2,4-Triazine and Pyrimido[4,5-c] Pyridazine Derivatives. EKB Journal Management System, 2(1), 15-22. doi: 10.21608/sjdfs.2013.194282
F. M.A El-Taweel; S. B.A. Said; S. M.A. Ramadan; A. A. Elagamey. "New and Facile Synthesis of Pyrimidine, Coumarine, Pyrimido[1,6-a]Pyrimidine, 1,2,4-Triazine and Pyrimido[4,5-c] Pyridazine Derivatives". EKB Journal Management System, 2, 1, 2013, 15-22. doi: 10.21608/sjdfs.2013.194282
El-Taweel, F., Said, S., Ramadan, S., Elagamey, A. (2013). 'New and Facile Synthesis of Pyrimidine, Coumarine, Pyrimido[1,6-a]Pyrimidine, 1,2,4-Triazine and Pyrimido[4,5-c] Pyridazine Derivatives', EKB Journal Management System, 2(1), pp. 15-22. doi: 10.21608/sjdfs.2013.194282
El-Taweel, F., Said, S., Ramadan, S., Elagamey, A. New and Facile Synthesis of Pyrimidine, Coumarine, Pyrimido[1,6-a]Pyrimidine, 1,2,4-Triazine and Pyrimido[4,5-c] Pyridazine Derivatives. EKB Journal Management System, 2013; 2(1): 15-22. doi: 10.21608/sjdfs.2013.194282

New and Facile Synthesis of Pyrimidine, Coumarine, Pyrimido[1,6-a]Pyrimidine, 1,2,4-Triazine and Pyrimido[4,5-c] Pyridazine Derivatives

Scientific Journal for Damietta Faculty of Science
Article 3, Volume 2, Issue 1, 2013, Pages 15-22    PDF (378.41 K)
Document Type: Original articles
DOI: 10.21608/sjdfs.2013.194282
Authors
F. M.A El-Taweel* 1; S. B.A. Said2; S. M.A. Ramadan2; A. A. Elagamey2
1Department of Chemistry, Faculty of Science, New Damietta City, Damietta University, Egypt
2Chemistry Department, Faculty of Science, Damietta University
Abstract
Condensation of cyanoacetylurea 1 with aromatic aldehydes gave the arylidenes 2a-d. Compound 2a cyclised to the pyrimidone 4 by boiling in DMF/Et3N. Compound 1 condensed with 2,4-dihydroybenzaldehyde to give the arylidene 6 .Cyclisation of 6 yield the coumarine 7.Coupling of 1 with aryl diazonium salts gave aryl hydrazones 9a,b. Compound 9a cyclised to 10 . Compound 10 reacted with malononitrile to give pyrimido [1,6-a] pyrimidine 11. Reaction of 9b with triethyl orthoformate and ethyl chloroformate afforded 1,2,4-triazines 13 and 15 respectively. Condensation of 1 with arylhydrazone 16 yielded pyrimido[4,5-c] pyridazine 19.
Keywords
Cyanoacetylurea; pyrimidine; coumarine; 1; 2; 4-triazine
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