BLOOD LIPID PROFILE IN CHILDREN WITH BRONCHIAL ASTHMA | ||||
| Al-Azhar Journal of Pediatrics | ||||
| Article 6, Volume 24, Issue 2, April 2021, Page 2037-2055 PDF (221.54 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/azjp.2021.194415 | ||||
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| Abstract | ||||
| Background: Bronchial asthma is a common, chronic respiratory disease affecting 1–18% of the population in different countries. Dyslipidemia is known to impact potently the development of atopy by promoting proatopic Th2 immunity and allergic inflammation. Objectives: This study was done to evaluate the lipid profile in asthmatic children and the correlations between the severity of bronchial asthma attacks in children as well as the level of control. Patients and methods: This cross-sectional comparative study was conducted on 100 patients with Bronchial Asthma enrolled from the Allergy-Pulmonology outpatient clinic Al-Hussien, Al-Azhar University hospital, Cairo-Egypt in the period from 2017-2019. The enrolled patients were divided into two groups according to GINA assessment of asthma control in children; group I: 50 patients with well controlled asthma and group II: 50 patients with uncontrolled asthma who were further subdivided into 30 partly controlled asthmatic children and 20 uncontrolled asthmatic children. Group II also subdivided according to attacks severity (asthma score) into mild (21 children, 42 %), moderate (15 children, 30 %) and severe (14 children, 28 %). All children were subjected to history taking, complete clinical examination, local systemic examination, pulmonary function tests and fasting lipid profile in blood, included serum Total Cholesterol (TC), serum Triglycerides (TG), serum High-Density Lipoprotein (HDL) and LDL cholesterol level (LDL). Results: TG and LDL were significantly higher in partly controlled and uncontrolled group compared with well controlled group (p ≤ 0.05 and p < 0.001 respectively), while HDL level was higher in well controlled group compared with partly controlled and uncontrolled group (p < 0.001). There was negative correlation between LDL and (FEV1 & FVC); also there was negative correlation between HDL and FEV1/FVC ratio in the mild attacks subgroup. There was negative correlation between TG and PEFR; also there was negative correlation between LDL and FEV1/FVC ratio in the severe attacks subgroup. Conclusion: There was positive correlation between LDL in uncontrolled more than partly controlled asthmatic children while negative correlation between HDL in uncontrolled more than partly controlled asthmatic children. | ||||
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