Histological Study on the Effects of Sofosbuvir and/or Ribavirin on Normal Rats | ||
| Scientific Journal for Damietta Faculty of Science | ||
| Volume 6, Issue 2, December 2016, Pages 144-149 PDF (737.68 K) | ||
| Document Type: Original articles | ||
| DOI: 10.21608/sjdfs.2016.194754 | ||
| Authors | ||
| Gamal A. Abdallah1; Kadry A. Elbakry* 1; Naglaa F. Elarabany1; Seeg A. Altamtam2 | ||
| 1Zoology Department, Faculty of Science, Damietta University | ||
| 2Zoology Department, Faculty of Science, Damietta University. | ||
| Abstract | ||
| The present study was conducted to demonstrate the histological effects of ribavirin and/or sofosbuvir on liver and kidney of rats. Rats were treated with ribavirin (0.0227 mg/kg body weight), sofosbuvir (0.01 mg/kg body weight) and mixture of ribavirin and sofosbuvir for 12 weeks. Liver and kidney were stained with H/E stain. Liver tissue also stained with AgNORs stain. The results showed that no histological alteration or abnormal counts were observed after treatment with ribavirin and / or sofosbuvir. Also the count of AgNORs is non-significantly differs between the normal non-treated rats and those treated with ribavirin and/or sofosbuvir. The present study concluded that, treatment with ribavirin and / or sofosbuvir or both has no side effects on normal rats. | ||
| Keywords | ||
| HCV; sofosbuvir; ribavirin; liver; kidney | ||
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