Mutagenicity Studies of Cadmium Chloride in Mice | ||
| Journal of High Institute of Public Health | ||
| Article 12, Volume 33, Issue 2, April 2003, Pages 359-372 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jhiph.2003.196787 | ||
| Authors | ||
| N A. Baeshin1; E S. Ahmed2; A Abo Yousef3; S J. Alam1 | ||
| 1Department of Biology, Faculty of Sciences, King Abdulaziz University, Saudi Arabia | ||
| 2Department of Biology, National Research Center, Cairo, Egypt | ||
| 3Department of Genetics, Faculty of Agriculture, Alexandria University, Egypt | ||
| Abstract | ||
| Cadmium chloride [CdCl2] was tested for its mutagenicity in Swiss albino mice by the dominant lethal mutantion test and the micronuclei test singly or in combination either with nitrosoguanidine [N.T.G.] or ascorbic acid. The results obtained showed that cadmium chloride was a weak mutagen when compared with N.T.G. as a positive control. However, cadmium chloride [CdCl2] and N.T.G. in combination showed significant increase in the dominant lethal mutations when compared with the effect of either [CdCl2] or N.T.G. individually. A statistically significant increase of the frequency of micronucleated erythrocytes was also noticed when CdCl, was combined with either N.T.G. or ascorbic acid as compared with CdCl2 individually. | ||
| Keywords | ||
| Cadmium Chloride; Mice | ||
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