Circulatory level of IL-6 and INF-γ in Sudanese leprosy patients | ||||
| Zagazig University Medical Journal | ||||
| Article 837, Volume 27, Issue 6, November 2021, Page 1568-1574 PDF (343.9 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2021.42403.1943 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hassan Gumaa Hamid  1; Amar Babikir Elhussein2; Omar Elteyb Fadlelseed3; Mohammed Helmi Shalayel4; Aamir Hamzza5; Soad Mohammed Alfadol6
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| 1Department of Biochemistry- Faculty of Medicine- Najran University | ||||
| 2Department of Biochemistry, Faculty of Medicine, Nile University, Khartoum, Sudan | ||||
| 3Department of biochemistry, Faculty of medicine, Najran University - Saudi Arabia | ||||
| 4Department of Biochemistry University of Hafr al Batin | ||||
| 5Department of Surgery, Faculty of medicine, University of Bahri - Sudan | ||||
| 6Department of Immunology, Central Laboratory, Ministry of Higher Education, Khartoum - Sudan | ||||
| Abstract | ||||
| ABSTRACT: Background: Leprosy is an infectious disease that affects the skin, peripheral nerves and mucosa caused by Mycobacterium leprae. It is considered as a public health problem for many countries. This study aimed to measure the level of IL-6 and INF-γ in the serum of leprosy patients to determine their role in the pathogenesis of the disease. Material and methods: This observational hospital-based case-control cross-sectional study includes 170 individuals, 110 were diagnosed with leprosy (78 male and 32 female), and 60 healthy control (44 male and 16 female). Blood samples were collected and IL-6 and INF-γ were measured by Sandwich ELISA using commercial kits. Results: Results revealed a significant difference (p < 0.001) in the concentration of serum levels of IL-6, INF-γ, and GLO among the studied groups, except for TP (p < 0.006). IL-6 shows a very highly statistically significant correlation with INF-γ in leprosy patients. INF-γ shows the highest concentration in no reaction group, then in type1 reaction group, type2 reaction group, and control group. IL-6 showed significant differences in lepers groups. The highest concentration was found in PB type lepers, followed by MB type. Conclusion: IL-6 and INF-γ levels were markedly increased in leprosy patients and their highest concentration obtained in (no reaction) group. Also levels of serum total proteins and globulins were significantly higher in leprosy patients. Serum cytokines estimation may aid in classifying various leprosy forms and reactions types | ||||
| Keywords | ||||
| Keywords: Interlukin-6 (IL-6); Interferon-γ (INF- γ); Pauci bacillary (PB); Multi bacillary (MB) | ||||
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