Relation between Thyroid Function and Iron Deficiency Anemia in Primary School-Age Children: A Controlled Cross-Sectional Study | ||||
| International Journal of Medical Arts | ||||
| Article 14, Volume 3, Issue 4, October 2021, Page 1855-1861 PDF (1.67 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2021.83720.1336 | ||||
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| Authors | ||||
Gamal Gheyath Gamal  1; Mohamed Zannoun2; Saad Ahmed Mohamed2; Gamal Ahmed Mohamed3
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| 1Department of Pediatrics, Damietta Faculty of Medicine; AL-Azhar University, Egypt | ||||
| 2Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt | ||||
| 3Department of Clinical Pathology, Damietta Faculty of Medicine; AL-Azhar University, Egypt | ||||
| Abstract | ||||
| Background: Iron deficiency anemia [IDA] is a very common medical condition affecting primary school-age children, with several unfavorable consequences. There are some reports pointing to a possible effect of IDA on thyroid gland function. Aim of the work: To assess thyroid function in primary school age children in Damietta Governorate, Egypt with iron deficiency anemia and to investigate potential related risk factors. Patients and Methods: A controlled cross-sectional study included 100 primary school age children [age: 6-12 years]; 50 children with iron deficiency anemia [case group], and 50 healthy age- and sex-matched children [control group]. Complete blood count, serum iron, serum ferritin and thyroid hormone profile [thyroid stimulating hormone [TSH], free triiodothyronine [FT3] and free thyroxine [FT4] were analyzed for all children. Results: In the case group, compared to the control group, there was a significantly higher TSH level [2.77±1.30 vs. 2.10±1.11; P=0.006] and lower FT3 [3.22±0.82 vs. 3.61±0.69; P=0.011]. The frequency of hypothyroid status [both overt and subclinical] was elevated in the case group [24% vs. 6%; P=0.02]. There was a significant negative correlation between TSH with both serum iron [P=0.019] and ferritin [P=0.009]. Conclusion: Iron deficiency anemia, especially when serum ferritin and iron are very low, in primary school children is associated with liability to get subclinical hypothyroidism. | ||||
| Keywords | ||||
| Thyroid; Primary school age; Egyptian; Iron deficiency; Anemia | ||||
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