Relation between Thyroid Function and Iron Deficiency Anemia in Primary School-Age Children: A Controlled Cross-Sectional Study | ||
| International Journal of Medical Arts | ||
| Article 14, Volume 3, Issue 4, October 2021, Pages 1855-1861 PDF (1.67 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2021.83720.1336 | ||
| Authors | ||
| Gamal Gheyath Gamal* 1; Mohamed Zannoun2; Saad Ahmed Mohamed2; Gamal Ahmed Mohamed3 | ||
| 1Department of Pediatrics, Damietta Faculty of Medicine; AL-Azhar University, Egypt | ||
| 2Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt | ||
| 3Department of Clinical Pathology, Damietta Faculty of Medicine; AL-Azhar University, Egypt | ||
| Abstract | ||
| Background: Iron deficiency anemia [IDA] is a very common medical condition affecting primary school-age children, with several unfavorable consequences. There are some reports pointing to a possible effect of IDA on thyroid gland function. Aim of the work: To assess thyroid function in primary school age children in Damietta Governorate, Egypt with iron deficiency anemia and to investigate potential related risk factors. Patients and Methods: A controlled cross-sectional study included 100 primary school age children [age: 6-12 years]; 50 children with iron deficiency anemia [case group], and 50 healthy age- and sex-matched children [control group]. Complete blood count, serum iron, serum ferritin and thyroid hormone profile [thyroid stimulating hormone [TSH], free triiodothyronine [FT3] and free thyroxine [FT4] were analyzed for all children. Results: In the case group, compared to the control group, there was a significantly higher TSH level [2.77±1.30 vs. 2.10±1.11; P=0.006] and lower FT3 [3.22±0.82 vs. 3.61±0.69; P=0.011]. The frequency of hypothyroid status [both overt and subclinical] was elevated in the case group [24% vs. 6%; P=0.02]. There was a significant negative correlation between TSH with both serum iron [P=0.019] and ferritin [P=0.009]. Conclusion: Iron deficiency anemia, especially when serum ferritin and iron are very low, in primary school children is associated with liability to get subclinical hypothyroidism. | ||
| Keywords | ||
| Thyroid; Primary school age; Egyptian; Iron deficiency; Anemia | ||
|
Statistics Article View: 1,374 PDF Download: 528 |
||
