Detection of the periodontal pathogen Porphyromonas Gingivalis in Oral Squamous Cell Carcinoma | ||
| Mansoura Journal of Dentistry | ||
| Article 5, Volume 7, Issue 3, September 2020, Pages 24-28 PDF (345.28 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjd.2020.198725 | ||
| Authors | ||
| Nehad M .Monier1; Islam M. Atteya2; Hamdia Askar3; Samah Helmy4 | ||
| 1Teaching assistant of oral medicine and periodontology, Faculty of Dentistry, Mansoura University, Egypt. | ||
| 2Lecturer of Oral medicine and periodontology, Faculty of Dentistry, Mansoura University, Egypt. | ||
| 3Professor of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Egypt. | ||
| 4Professor of Oral medicine and periodontology, Faculty of Dentistry, Mansoura University, Egypt | ||
| Abstract | ||
| Background: The concept of infection-based carcinogenesis is gaining an increasing attention. Also periodontitis has been extensively studied as possible risk factor for gastrointestinal cancers including oral cancer. Methodology: Using conventional PCR, we detected the presence of the key periodontal pathogen Porphyromonas gingivalis (P. gingivalis) in 25 oral cancer fresh tissue specimens versus 25 healthy oral mucosal tissue.. Results: P. gingivalis showed significantly higher prevalence in control group with slightly higher loads in cancer tissue. Bacterial presence was not found to be correlated with tumor progression. Conclusion: P. gingivalis was not found to play a possible role in the cancerous lesion. More studies should be implemented to investigate the bacterial involvement in the oral tumors. | ||
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