Pomegranate molasses and red grape vinegar: can they alleviate dysplastic changes in chemically induced oral squamous cell carcinoma in hamsters?
Ezzat, S., Elsherbini, A., Esmaeil, D., Abdulrahman, M. (2021). Pomegranate molasses and red grape vinegar: can they alleviate dysplastic changes in chemically induced oral squamous cell carcinoma in hamsters?. EKB Journal Management System, 67(4), 3137-3146. doi: 10.21608/edj.2021.79089.1662
Samah Ezzat; Amira Elsherbini; Doaa Esmaeil; Mohamed Abdulrahman. "Pomegranate molasses and red grape vinegar: can they alleviate dysplastic changes in chemically induced oral squamous cell carcinoma in hamsters?". EKB Journal Management System, 67, 4, 2021, 3137-3146. doi: 10.21608/edj.2021.79089.1662
Ezzat, S., Elsherbini, A., Esmaeil, D., Abdulrahman, M. (2021). 'Pomegranate molasses and red grape vinegar: can they alleviate dysplastic changes in chemically induced oral squamous cell carcinoma in hamsters?', EKB Journal Management System, 67(4), pp. 3137-3146. doi: 10.21608/edj.2021.79089.1662
Ezzat, S., Elsherbini, A., Esmaeil, D., Abdulrahman, M. Pomegranate molasses and red grape vinegar: can they alleviate dysplastic changes in chemically induced oral squamous cell carcinoma in hamsters?. EKB Journal Management System, 2021; 67(4): 3137-3146. doi: 10.21608/edj.2021.79089.1662

Pomegranate molasses and red grape vinegar: can they alleviate dysplastic changes in chemically induced oral squamous cell carcinoma in hamsters?

Egyptian Dental Journal
Article 4, Volume 67, Issue 4 - Serial Number 3, October 2021, Page 3137-3146  XML PDF (3.27 MB)
Document Type: Original Article
DOI: 10.21608/edj.2021.79089.1662
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Authors
Samah Ezzatorcid 1; Amira Elsherbiniorcid 1; Doaa Esmaeilorcid 2; Mohamed Abdulrahman email orcid 3
1Lecturer of Oral Biology, Faculty of Dentistry, Mansoura University, Egypt
2Lecturer of Oral Pathology, Faculty of Dentistry, Mansoura University, Egypt
3Associate professor of Oral Biology, Faculty of Dentistry, Mansoura University, Egypt
Abstract
76 male hamsters were divided equally into 4 groups (19 each). Group I served as control group with no intervention. Group II received topical application of 0.5% 7, 12-dimethylbenz[a]anthracene (DMBA) on the left buccal pouches for 16week with no intervention. Group III received a 0.5ml of Pomegranate molasses plus 0.5 ml distilled water through ingestion daily concomitant with DMBA application and continued for 3 months post induction period. Group IV received a red grape vinegar in a protocol similar to group III. Then the pouches were collected fixed and processed for H&E, anti-TGF-β and anti-CK-19 staining.
Results: group II showed classical dysplastic changes with statistically significant higher expression of anti-TGF-β and CK-19 (P<0.0001) compared to group III and IV. The later showed reduction of dysplastic changes and anti-TGF-β and CK-19 expression. There was no significant difference between the two treatment modalities.
Conclusion: Both pomegranate molasses and red grape vinegar reduced the signs of dysplasia via reduction of TGF-β and CK-19 expression and consequently reduction of the EMT. Both pomegranate molassess and red grape vinegar represent a promising protective therapeutic modality for reduction of dysplastia and carcinogenesis.
Keywords
Epithelial mesenchymal interactions; pomegranate molasses; red grape vinegar; DMBA
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