Pomegranate molasses and red grape vinegar: can they alleviate dysplastic changes in chemically induced oral squamous cell carcinoma in hamsters? | ||
| Egyptian Dental Journal | ||
| Article 4, Volume 67, Issue 4 - Serial Number 3, October 2021, Pages 3137-3146 PDF (3.27 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2021.79089.1662 | ||
| Authors | ||
| Samah Ezzat1; Amira Elsherbini1; Doaa Esmaeil2; Mohamed Abdulrahman* 3 | ||
| 1Lecturer of Oral Biology, Faculty of Dentistry, Mansoura University, Egypt | ||
| 2Lecturer of Oral Pathology, Faculty of Dentistry, Mansoura University, Egypt | ||
| 3Associate professor of Oral Biology, Faculty of Dentistry, Mansoura University, Egypt | ||
| Abstract | ||
| 76 male hamsters were divided equally into 4 groups (19 each). Group I served as control group with no intervention. Group II received topical application of 0.5% 7, 12-dimethylbenz[a]anthracene (DMBA) on the left buccal pouches for 16week with no intervention. Group III received a 0.5ml of Pomegranate molasses plus 0.5 ml distilled water through ingestion daily concomitant with DMBA application and continued for 3 months post induction period. Group IV received a red grape vinegar in a protocol similar to group III. Then the pouches were collected fixed and processed for H&E, anti-TGF-β and anti-CK-19 staining. Results: group II showed classical dysplastic changes with statistically significant higher expression of anti-TGF-β and CK-19 (P<0.0001) compared to group III and IV. The later showed reduction of dysplastic changes and anti-TGF-β and CK-19 expression. There was no significant difference between the two treatment modalities. Conclusion: Both pomegranate molasses and red grape vinegar reduced the signs of dysplasia via reduction of TGF-β and CK-19 expression and consequently reduction of the EMT. Both pomegranate molassess and red grape vinegar represent a promising protective therapeutic modality for reduction of dysplastia and carcinogenesis. | ||
| Keywords | ||
| Epithelial mesenchymal interactions; pomegranate molasses; red grape vinegar; DMBA | ||
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