Effect of Platelet Rich Plasma on Corneal Alkali Burn Ulcer in Rabbits | ||
| Journal of Current Veterinary Research | ||
| Article 9, Volume 3, Issue 2, October 2021, Pages 73-83 PDF (1.25 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcvr.2021.199438 | ||
| Authors | ||
| Mahmoud Atiya Hassan* 1; Fatma AboZakaib2; Nani Nasr El-din3; Marwa Elzeftawy4; Mahmoud Nasif5; Mohamed El-Sherif6 | ||
| 1Surgery department, Faculty of veterinary medicine, New valley university | ||
| 2Department of Pathology and clinical Pathology, Faculty of Veterinary Medicine, Sohag University. | ||
| 3Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, New Valley University. | ||
| 4Department of Biochemistry, Faculty of Veterinary Medicine, New Valley University. | ||
| 5Department of surgery, Anesthesiology & Radiology, Faculty of Veterinary Medicine, Assiut University. | ||
| 6Department of surgery, Anesthesiology & Radiology, Faculty of Veterinary Medicine, New Valley University. | ||
| Abstract | ||
| Objective of this study to assess the efficacy of platelet rich plasma (PRP) in the treatment of extensive corneal ulcers in albino rabbits with two different administration techniques. A total of 24 rabbits were used in this study. After collecting intracardiac blood samples, platelet-rich plasma was obtained by double centrifugation. Alkali burns were inflicted on the central corneas of all rabbits using a sterile swab soaked in 1 M NaOH for 60s. Only Left eye in each rabbit was used. Animals were divided into 4 groups. GroupI (n=6) normal control group received PRP drop twice daily with 8-h intervals for 7 successive days. whereas group II (n = 6) did not receive any treatment and served as the control untreated group. The third group (n = 6) received only one-shot of subconjunctival PRP. The fourth group (n=6) received PRP drop twice daily with 8-h intervals for 7 successive days. Corneal histopathology was investigated for epithelial regeneration, presence of inflammation, and structural integrity of fibroblasts. Data were expressed as mean ± standard deviations. Data from experimental groups were statically analyzed using one-way ANOVA with Turkey’s post hoc multiple comparisons tests using the GraphPad Prism software version 5 (San Diego, CA, USA) and P | ||
| Keywords | ||
| Alkali-burn; cornea; PRP; Subconjunctival; ulcer | ||
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