Cardioprotective effect of melatonin on ischemic heart disease clinical course in elderly patients with insomnia | ||
| Egyptian Journal of Chemistry | ||
| Article 62, Volume 65, Issue 4, April 2022, Pages 693-700 PDF (353.66 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.93831.4420 | ||
| Authors | ||
| Mikhail A. Osadchuk1; Inna N. Vasil`eva1; Nikolay P. Korzhenkov1; Ekaterina D. Mironova1; Maxim V. Trushin* 2 | ||
| 1Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia | ||
| 2Kazan Federal University, Kazan, Russia | ||
| Abstract | ||
| We aimed at studying the exogenous melatonin corrective effect on Ischemic heart disease (IHD) clinical features in elderly patients with sleep disorders. A total of 60 patients aged from 60 to 74 with IHD, angina pectoris functional class (FC) II and complaints of sleep disorder were examined. Patients of the 1st group (n = 30), received basic therapy: acetylsalicylic acid, atorvastatin and metoprolol succinate. A chemical melatonin analogue once a day was added to the basic treatment regimen of patients of the 2nd group (n = 30). Timely correction of melatonin pathogenetic deficiency in elderly IHD patients with insomnia by including its pharmacological analogues in the treatment regimen manifests significant improvement in the patients` clinical condition. This is evidenced by the following: a decrease in anginal attacks frequency, dynamics in Holter electrocardiographic study (ECG) monitoring indicators and somnological characteristics. | ||
| Keywords | ||
| Ischemic heart disease; Melatonin; Insomnia | ||
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