Relation between Interleukin 8 and Bronchial Asthma in Children: Review Article | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 24, Volume 85, Issue 2, October 2021, Pages 3621-3623 PDF (369.85 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2021.201975 | ||
| Authors | ||
| Sahbaa Fehr Mohamed; Fathy Mohamed Abd-Elwahab* ; Dina Mohamed Shokry; Walaa Mohamed Samy | ||
| Abstract | ||
| Background: Asthma is a frequent respiratory condition to treat. A persistent airway inflammation characterizes this frequent form of pulmonary disease. Immune responses are triggered by cytokines and chemokines produced by airway epithelial cells. Human bronchial epithelial cells secrete IL-8 in response to the presence of interleukin-4 (IL-4) and interleukin-13, both of which are increased in asthmatics. There are two receptors for IL-8, the IL-8 receptor alpha (also known as CXCR1) and beta (also known as the IL-8 RB, CXCR2). IL8 is a potent chemotactic cytokine that activates inflammatory cells by recruiting mast cells, mononuclear phagocytes T lymphocytes, and neutrophils to the site of inflammation. Objective: To determine the relationship between IL8 and bronchial asthma in children. Conclusion: The assessment of IL8 levels in pediatric asthmatic patients is a useful biomarker reflecting the status of asthma and also to glucocorticoids and treatment responses. | ||
| Keywords | ||
| Bronchial asthma; Interleukin 8 | ||
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