The Antidepressant-like Effect of Mitragyna Speciosa Korth
Abushwereb, H., Abdulatiff, A., Abdulmajeed, A. (2018). The Antidepressant-like Effect of Mitragyna Speciosa Korth. EKB Journal Management System, 4(2), 40-43. doi: 10.18576/jpac/040205
Hanan Abushwereb; Aisha Abdulatiff; Abubaker Abdulmajeed. "The Antidepressant-like Effect of Mitragyna Speciosa Korth". EKB Journal Management System, 4, 2, 2018, 40-43. doi: 10.18576/jpac/040205
Abushwereb, H., Abdulatiff, A., Abdulmajeed, A. (2018). 'The Antidepressant-like Effect of Mitragyna Speciosa Korth', EKB Journal Management System, 4(2), pp. 40-43. doi: 10.18576/jpac/040205
Abushwereb, H., Abdulatiff, A., Abdulmajeed, A. The Antidepressant-like Effect of Mitragyna Speciosa Korth. EKB Journal Management System, 2018; 4(2): 40-43. doi: 10.18576/jpac/040205

The Antidepressant-like Effect of Mitragyna Speciosa Korth

Journal of Pharmaceutical and Applied Chemistry
Volume 4, Issue 2, May 2018, Page 40-43  XML PDF (493.99 K)
Document Type: Original Article
DOI: 10.18576/jpac/040205
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Authors
Hanan Abushwereb1; Aisha Abdulatiff2; Abubaker Abdulmajeed2
1Pharmacology and Clinical Pharmacy Department, University of Tripoli, Faculty of Pharmacy, Tripoli, Libya.
2Pharmacology Department, Faculty of Pharmacy, Universiti Sains Malaysia, Penang, Malaysia.
Abstract
Mitragyna Speciosa Korth (MS) was used as an opium substitute in Southeast Asia. It has been shown to have addictive properties and to produce tolerance and dependence. The methanolic leaf extract of Mitragyna Speciosais Known to contain several alkaloids including mitragynine which structurally has an indole moiety. This moiety is also a feature of serotonin which is an important neurotransmitter in depression. This would tend to suggest some activities of MS at the brain serotonergic system. On the other hand, current strategy in designing antidepressants in the form of selective serotonin reuptake inhibitors (SSRIs), this study has investigated whether the methanolic leaf extract of MS possesses antidepressant-like effect. The Porsolt swim test method (PST) for screening antidepressants had been used. Female mice were forced to swim for 6 minutes. This was followed 24h later with a second swim session of 6 min. Drugs were administered (n=10) orally1, 5 and 24h after the first swim session to record chronic effect. The oral administration of MS methanolic leaf extract at doses 100, 200, 400 mg/kg, significantly reduced the immobility time.

Keywords
 Mitragyna Speciosa; Mitragynine; Selective Serotonin Reuptake Inhibitors; Antidepressant effects
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