In Vitro Antiproliferative and Antimicrobial Activity of 11-Epiartapshin Compound Isolated from SeriphidiumHerba-alba | ||||
| Journal of Pharmaceutical and Applied Chemistry | ||||
| Volume 4, Issue 2, May 2018, Page 67-74 PDF (827.42 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.18576/jpac/040210 | ||||
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| Authors | ||||
| M.Taher M. El-Wassimy1; Mehawed M. Ahmed1; Sabry H. H. Younes1; Mohamed- Elamir F. Hegazy2 | ||||
| 1Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt. | ||||
| 2PhytochemistryDepartment, National Research Centre, Giza 12622, Egypt. | ||||
| Abstract | ||||
| Seriphidium herba-alba (Asteraceae family) was known for its therapeutic and medicinal properties, it was used in both traditional and modern medicine. 11-Epiartapshin was isolated from S. herba-alba. The structure of the compound was elucidated by means of spectroscopic data analysis, including 1D/2D NMR techniques and compared with reported data from the literature. The isolated compound was subjected to antiproliferative potential activity against cancer cell lines of the liver (HepG-2), colon (HCT-116) and breast (MCF-7) using 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction Assay. As well as, the total extract of S. herba-alba and the purified 11-epiartapshin were tested for antimicrobial activity. 11-Epiartapshin showed moderate antibacterial effects against Gram-positive, Gram-negative bacteria and weak antifungal effect. Seriphidiumherba-alba total extract has good inhibitory activity against all tested pathogenic bacteria. | ||||
| Keywords | ||||
| Seriphidium herba-alba; 11-Epiartapshin; HepG-2; HCT-116; MCF-7 | ||||
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