Hetarylcyanamides: Synthesis of Novel Thiazole, Triazole and Pyrimidine Derivatives and Prediction of their Biological Activity via PASS Inet
Khodairy, A., Moustafa, A., W. Ahmed, W. (2017). Hetarylcyanamides: Synthesis of Novel Thiazole, Triazole and Pyrimidine Derivatives and Prediction of their Biological Activity via PASS Inet. EKB Journal Management System, 3(2), 1-7. doi: 10.18576/jpac/030310
Ahmed Khodairy; Amr H. Moustafa; Walaa W. Ahmed. "Hetarylcyanamides: Synthesis of Novel Thiazole, Triazole and Pyrimidine Derivatives and Prediction of their Biological Activity via PASS Inet". EKB Journal Management System, 3, 2, 2017, 1-7. doi: 10.18576/jpac/030310
Khodairy, A., Moustafa, A., W. Ahmed, W. (2017). 'Hetarylcyanamides: Synthesis of Novel Thiazole, Triazole and Pyrimidine Derivatives and Prediction of their Biological Activity via PASS Inet', EKB Journal Management System, 3(2), pp. 1-7. doi: 10.18576/jpac/030310
Khodairy, A., Moustafa, A., W. Ahmed, W. Hetarylcyanamides: Synthesis of Novel Thiazole, Triazole and Pyrimidine Derivatives and Prediction of their Biological Activity via PASS Inet. EKB Journal Management System, 2017; 3(2): 1-7. doi: 10.18576/jpac/030310

Hetarylcyanamides: Synthesis of Novel Thiazole, Triazole and Pyrimidine Derivatives and Prediction of their Biological Activity via PASS Inet

Journal of Pharmaceutical and Applied Chemistry
Volume 3, Issue 2, September 2017, Pages 1-7    PDF (853.36 K)
Document Type: Original Article
DOI: 10.18576/jpac/030310
Authors
Ahmed Khodairy; Amr H. Moustafa; Walaa W. Ahmed
Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt
Abstract
Some new N-thiazolylaminopyrimidine derivatives 3a,b have been synthesized via the reaction of 1-(4,6-
dimethylpyrimidin-2-yl)thiourea 2, obtained via sulfidation of cyanamide 1a with phenacyl bromides. Acid hydrolysis of
N-(pyrimidin-2-yl)cyanamides 1b,c gave the corresponding pyrimidinylurea derivatives 4a,b. Reaction of cyanamide 1b
with thieno[2,3-b]thiophene derivative 5, at molar ratios (1:1 or 2:1), gave the unexpected thienopyrimidine derivative 6,
not the expected bis-thienopyrimidine derivative 7. Triazolylaminopyrimidine derivative 8 has been obtained via the
heterocyclization reaction of cyanamide 1b with benzhydrazide. Prediction the activity spectra of synthesized compounds
using PASS Inet at Pa > 70%, showing high probability of Mucomembranous protector, Transcription factor STAT
inhibitor and Gluconate 2-dehydrogenase (acceptor) inhibitor.

Keywords
 Hetarylcyanamide; Aminothiazole; Thienopyrimidine; Aminotriazole; PASS Inet
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