Prediabetes: profile of hematological indices in Iraqi patients | ||||
| Egyptian Journal of Chemistry | ||||
| Article 58, Volume 65, Issue 5, May 2022, Page 615-621 PDF (353.7 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.100299.4666 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ola H. Jasim 1; Majid M. Mahmood  1; Ali H. Ad’hiah 2
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| 1Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq | ||||
| 2Tropical-Biological Research Unit, College of Science, University of Baghdad. | ||||
| Abstract | ||||
| Prediabetes has been a target for research to understand good predictors of prediabetes. this cross-sectional study sought to analyze the predictive significance of WBC and neutrophil counts, as wellas NLR prediabetes in Iraqi adults. Three groups of individuals have included: 30 apparently healthy individuals (normoglycemia), 125 prediabetics, and 30 patients with type 2 diabetes mellitus (T2DM).Results revealed that fasting blood glucose(FBG) median was significantly higher in prediabetics (106.6 [IQR: 103.7-112.5] vs.80.2 [IQR: 77.1-86.1] mg/dL; p < 0.001) or diabetics (157.14 [133.0-181.2]vs.80.2 [IQR: 77.1-86.1] mg/dL; p < 0.001) than in normoglycemic. The Hb1Ac showed a similar significant increase in prediabetics and diabetics compared to normoglycemic. It was also noted that both parameters were significantly elevated in diabetics compared to prediabetics. The total count of WBCs was significantly higher in prediabetics and diabetics compared to normoglycemic (7.5 ± 2.1 and 8.0 ± 2.4 vs. 6.5 ± 1.3 ×109/L; p = 0.020), while there was no significant difference between prediabetics and diabetics in this context. A similar pattern of a significantly increased count of neutrophils was observed in prediabetics and diabetics compared to normoglycemic. The NLR was significantly higher in prediabetics (1.67 [IQR: 1.30-2.22]; p = 0.016) and diabetics (1.65 [IQR: 1.33-2.32]; p = 0.021) than in normoglycemic (1.40 [IQR: 1.12-1.72]), while the NLR showed no significant difference between prediabetics and diabetics (p = 0.577). ROC curve analysis revealed that the NLR had an approximated area under the curve in prediabetes and diabetes (0.641 and 0.674, respectively), but the sensitivity and sensitivity were slightly higher in prediabetes than diabetes (58.4 and 60. 0% vs. 55.2 and 56.7%, respectively). Logistic regression analysis revealed that the NLR was associated with a similar risk in the development of prediabetes (OR = 2.61; 95% CI = 1.12 - 6.07; p = 0.027) and diabetes (OR = 3.05; 95% CI = 1.07 - 8.68; p = 0.067), but the p-value in diabetes was not significant. | ||||
| Keywords | ||||
| Prediabetes; Diabetes; Hematological indices; Neutrophil-to-lymphocyte ratio | ||||
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