Anti-ficolin-2 Antibody: Could it be a Predictor of Proliferative Lupus Nephritis in Lupus Patients? | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 68, Volume 85, Issue 2, October 2021, Pages 3865-3871 PDF (697.93 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2021.205090 | ||
| Authors | ||
| Sylvia Talaat Kamal* ; Mohamed Nazmy Farres; Rehab Ali Ibrahim; Ibrahim Sami Ibrahim; Fatma Abdelrahman Ahmed | ||
| Abstract | ||
| Background: Nephritis is a challenging domain of systemic lupus erythematosus (SLE). There is a growing need for identification of a non-invasive marker for diagnosing and monitoring nephritis. Objective: To explore the relevance of using anti-ficolin-2 antibody (Anti-FCN2) as a biomarker for detecting lupus nephritis (LN), and its relation to renal biopsy histopathology and disease activity. Patients and Methods: Sixty SLE patients were compared to 30 apparently healthy individuals. Thirty of the patients were LN patients (documented by a recent renal biopsy). Full history, examination and laboratory investigations were done. Activity was assessed by SLE disease activity index (SLEDAI) score, and Anti-FCN2 titer was measured by enzyme-linked immunosorbent assay technique (ELISA). Results: Forty-four of our SLE patients were in disease activity by SLEDAI score. Anti-FCN2 titer was significantly higher among SLE patients compared to control group (p value <0.001). It was also higher among patients with high disease activity compared to those with low disease activity and cutoff value was at 37 ng/ml (p value is <0.001). Anti-FCN2 titer was significantly higher among patients with LN compared to those without LN (p value is <0.001) with best cutoff value at 72.50 ng/ml. Regarding LN patients, it was significantly higher among patients with proliferative changes than LN patients with non-proliferative changes (p value is 0.05) with best cutoff value at 155 ng/ml. Conclusion: Anti-FCN2 shows promising results as a biomarker for lupus disease activity, especially regarding LN and proliferative changes. Further longitudinal studies on larger samples are needed to confirm. | ||
| Keywords | ||
| Anti-ficolin-2 antibody; Biomarker; Lupus activity; Lupus nephritis; Systemic lupus erythematosus | ||
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