THERAPEUTIC EFFECTS EVALUATION OF VITAMIN E ALONE AND IN COMBINATION WITH RANITIDINE IN STRESS – INDUCED GASTRIC ULCERS IN RATS

It is noteworthy to examine the efficacies of vitamin E and its combination with an
antagonist of histamine receptor 2 in the treatment of stress gastric ulcers. Animals were
divided into 6 groups; group 1 (normal control), group 2 (Cold – restraint stress; CRS), group
3 (ranitidine 20 mg/kg), group 4 (vitamin E 100 mg/kg), group 5 (ranitidine 10 mg/kg + vitamin
E 50 mg/kg ), group 6 (ranitidine 5 mg/kg + vitamin E 50 mg/kg ). Drugs were administered
orally for 7 consecutive days 1 hour after induction of the gastric injury. Rats were sacrificed.
The assessment of stomach damage was by body weight observation, macroscopic
examinations, histological study, and determination of oxidative stress markers (MDA stomach
content and SOD enzyme activity). Present findings showed that the using of vitamin E with
ranitidine is dose-dependent, and more effective than using vitamin E alone in the management
of stress-induced lesions. Vitamin E caused a remarkable body weight decrease.