RENOPROTECTIVE EFFECT OF TAXIFOLIN AND/OR VITAMIN C ON DIAZINON-INDUCED RENAL INJURY IN RATS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 30, Volume 44, Issue 2, December 2021, Pages 647-656 PDF (872.07 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2021.207197 | ||
| Authors | ||
| Shahad M. Najeb1; Ausama Ayob Jaccob* 2; Muhsin S.G. AL-Moziel2; Hayder Mohammed Abdulhameed1 | ||
| 1Basrah Health Directory, Iraq | ||
| 2Department of Pharmacology and Toxicology, Pharmacy College, Basrah University, Iraq | ||
| Abstract | ||
| Insecticides have come to be used in a wrong way and uncontrollably, leading to an increase in the incidence of chronic diseases such as chronic nephropathies, diabetes, and other metabolic disorders. Objective: To evaluate the protective effect of Taxifolin and/or vitamin C against Diazinon-induced renal dysfunction. Methods: Thirty-six female rats were divided into six groups gavaged orally for 30 days. Group 1 received 20 mg/kg DZN. Group 2 received 25 mg/kg Taxifolin, 100 mg/kg vitamin C, and then 20 mg/kg DZN. Group 3 received 25 mg/kg Taxifolin and then 20 mg/kg DZN. Group 4 received 100 mg/kg vitamin C and then 20 mg/kg DZN. Group 5 received 25 mg/kg Taxifolin and then 100 mg/kg vitamin C. Finally, group 6 received distilled water. In the end, the rats were sacrificed and their blood and kidneys were collected for biochemical analysis and histopathology. Conclusion: Sub-acute administration of Taxifolin and vitamin C provides a renoprotective effect against oxidative stress induced by DZN. | ||
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