Cathodic Stripping Voltammetric Determination of Lisinopril in Dosage Forms and Biological Fluids | ||
| Egyptian Journal of Chemistry | ||
| Article 41, Volume 65, Issue 7, July 2022, Pages 421-428 PDF (438.49 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.104642.4835 | ||
| Authors | ||
| Badriah Saad Al–Farhan1; Ahmed A. Gahlan2; Ahmed M. Haredy* 3; Othman A. Fraghly2, 4 | ||
| 1Chemistry Department, Faculty of Girls for Science, King Khalid University, Abha, Kingdom of Saudi Arabia | ||
| 2Chemistry Department, Faculty of Science, Al –Azhar University, Assiut Branch, 71524, Assiut, Egypt | ||
| 3Pharmaceutical Analytical Department, Faculty of Pharmacy, Merit University, New Sohag, Egypt | ||
| 4Chemistry Department, Faculty of Science, Al Baha University, Al Baha, Kingdom of Saudi Arabia | ||
| Abstract | ||
| Lisinopril (LSP) in pharmaceutical dosage forms and biological fluids was studied using the square wave cathodic stripping voltammetric method (SWCSV) at a carbon paste electrode (CPE). To maximize the method's circumstances, many parameters were defined. The linear concentration range of 3.53 – 44.17 ng/mL was effectively determined at ideal conditions of 0.08 M Britton-Robinson buffers (pH = 9.00) at accumulation times 15, 30 sec., and 2.64 – 44.17 ng/mL at 60 sec. With good results, the standard addition method was employed to determine LSP in pure solutions, tablets, and biological fluids. The proposed method is compared to the previously published standard method. | ||
| Keywords | ||
| Lisinopril, Cathodic Stripping Voltammetric, Dosage Forms; Biological Fluids | ||
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