Prevalence of Selective IgA Deficiency in a Sample of Egyptian Patients with Type1 Diabetes Mellitus | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 4, Volume 86, Issue 1, January 2022, Pages 17-21 PDF (496.87 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2021.209971 | ||
| Authors | ||
| Hoda Mohamed Elsayed; Fawzia Hassan Abou Ali; Dina Sayed Sheha; Nesma Ali Ibrahim; Yasmin Sayed Sharawy; Sylvia Talaat Kamal* | ||
| Abstract | ||
| Background: Selective Immunoglobulin A deficiency (SIgAD) is known to be one of the most frequent primary immunodeficiency diseases. Several studies worldwide confirm the increased frequency of this disease among type 1 diabetes mellitus (T1DM), yet this has not been studied in Egypt. Objective: This work aimed to define the prevalence of SIgAD among Egyptian patients with T1DM. Patients and Methods: Fifty patients with T1DM were compared to fifty apparently healthy individuals. Serum levels of IgA, IgG, and Immunoglobulin M (IgM) levels were measured by Nephelometry to all participants. Results: The mean age of the diabetic group was 24.5 ± 5.3 years. Thirty out of fifty patients with T1DM (60%) were diagnosed as SIgAD with, female predominance (66.7% of SIgAD). We also found a significant relationship between SIgAD and diabetic ketoacidosis (P-value<0.001). Serum IgA levels were positively correlated to IgG and IgM. Conclusion: The current study displays 60% prevalence of SIgAD among adult Egyptians with T1DM, which is higher than stated in other countries. | ||
| Keywords | ||
| Diabetes Mellitus; SIgAD; HbA1C | ||
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