Polymorphism RS2227306 In The Interleukin 8 Gene and Its Relation to Bronchial Asthma: Review Article | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 9, Volume 86, Issue 1, January 2022, Pages 50-53 PDF (731.44 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2021.209977 | ||
| Authors | ||
| Sahbaa Fehr Mohamed Hafez; Osama Taha Amer* ; Osama Abd Elaziz Mostafa; Walaa Mohamed Samy | ||
| Abstract | ||
| Background: Allergy symptoms such as wheezing, breathlessness, and coughing are all symptoms of asthma, which is a long-term respiratory condition characterized by inflammation and reversible airway blockage. If you're a child or young adult, asthma is the most common long-term condition, with more severe symptoms. The CXC chemokine superfamily includes the Interleukin 8 (IL-8) chemokine. T lymphocytes, neutrophils, and mast cells are all chemotactic cytokines that IL-8 attracts in the body. A polymorphism in the promoter region of IL-8 - 781C/T (rs2227306) has been found to be associated with an elevated level of the cytokine IL-8. There is a gene in the first intron of the IL-8 - 781C/T (rs2227306) that has been reported to aid in both gene transcription and gene regulation. Objective: The aim of the present review was to study polymorphism RS2227306 in the interleukin 8 gene and its relation to bronchial asthma. Conclusion: IL8 polymorphism rs2227306 has the potential to be utilized as a marker in interpretation of assessment of severity of asthma. | ||
| Keywords | ||
| Polymorphism Rs2227306; Interleukin 8; Bronchial asthma | ||
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