Soft versus Conventional Protocol in Ovarian Stimulation in Intracytoplasmic Sperm Injection Cycles for Poor Responders: A randomized clinical trial | ||
| SVU-International Journal of Medical Sciences | ||
| Article 20, Volume 5, Issue 1, January 2022, Pages 188-196 PDF (338.41 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2021.108815.1249 | ||
| Authors | ||
| Abd El-Naser Abd El-Gaber Ali; Ahmed Hashem Abdellah; Ahmed Hamdy Mohammed* ; Hazem Hashim Ahmed | ||
| Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt | ||
| Abstract | ||
| Background: Mild(soft, minimal) protocols have been proposed as an alternative to the classical protocols , a controlled ovarian stimulation is defined as “soft” either when (a) Gonadotrophins (Gn) are given at a lower dose and/or for a short period together with a GnRH-antagonist, or when (b) oral compounds (e.g. anti-estrogens) are used alone or in combination with Gn and GnRH-antagonists. Objectives: The aim of this study was to compare between soft and conventional protocol in ovarian stimulation for poor responders women undergoing Intracytoplasmic sperm injection procedure(ICSI). Patients and methods: This study is A randomized clinical trial, carried out at Assisted Reproduction Unit, Qena University hospital, South Valley University, Egypt, on 120poor responder women undergoing ICSI divided randomly into two groups:(Group 1): included 60 patients received soft ovarian stimulation protocol, (Group 2): included 60 patients received conventional ovarian stimulation protocol. Results: In comparison between the two groups regarding cancellation rate ,chemical and clinical pregnancy were comparable with no statistically significance between soft group and conventional group. Conclusion: This analysis presents strong evidence in favor of soft stimulation in intracytoplasmic sperm injection cycles for poor responders, which therefore should currently be considered a treatment of choice for patients requiring intracytoplasmic sperm injection cycles for poor responder's treatment. | ||
| Keywords | ||
| soft; conventional; poor responder; ICSI | ||
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