BIOTECHNOLOGY APPROACH TO PERFORM A COMPUTATIONAL MODEL OF BEE VENOM AGAINST COVID-19 | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 12, Volume 51, Issue 3, December 2021, Pages 533-538 PDF (1.02 M) | ||
| DOI: 10.21608/jesp.2021.210439 | ||
| Authors | ||
| EMAN ALAAELDIN ABDELFATTAH1; MAMDOUH I. NASSAR1; SOHA M. MOHAMED2; DINA H. ABD EL-MONEM1; SAMAR M. IBRAHIM3; MAI YOUSSEF4; HADEER OSAMA FATHY4 | ||
| 1Department of Entomology | ||
| 2Faculty of Science, Hospital Misr University for Science and Technology | ||
| 3Micro-analytical Center | ||
| 4Biotechnology Program, Faculty of Science, Cairo University | ||
| Abstract | ||
| Arthropod venoms have multiple effect on antivirus and antibacterial infection especially, bee venom (BV), which has a specific character among other due to its ant-proliferative potential, antiviral, antimicrobial and antitumor activity. Venom-based drugs as Captopril® & Ribavirim ® are used as antiviral and anticancer drug. Empathetic the action mechanism of venompeptides increase the drug specificity against virus cells. A new coronavirus (SARS-CoV-2) leads to an incipient coronavirus disease (COVID-19). COVID-19 virus belongs to genus Betacorona virus that includes MERS-CoV & SARS-CoV. The study evaluated venom derivatives and antiviral drugs against COVID-19 envelope protein (EP) and spike protein (SP) sequences. In this study, sequence analysis, protein modeling, & molecular docking were used for COVID-19 EP, and SP, to build a model of testing venom derivatives and antiviral drugs against COVID-19 EP, and SP. Approved drugs includes Remdisivir®, Ledipasvir® (antiviral drugs), Captopril®, & Ribavirim® (as venom antiviral drug derivatives). | ||
| Keywords | ||
| COVID-19; Venom antiviral; Coronavirus; Multiple sequence alignment; Molecular docking; Protein modeling | ||
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