Correlation between serum 25-hydroxyvitamin D levels and VEP and OCT in patients with primary open-angle glaucoma | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 3, Volume 42, Issue 1, January 2022, Pages 27-38 PDF (413.78 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2021.71460.1100 | ||
| Authors | ||
| hassan Lotfy Fahmy1; Anwar Mohammed Ali2; Sally Anwar Sayed* 3; Mohammed Anwar Sayed1 | ||
| 1Department of Ophthalmology, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt. | ||
| 2Department of Neurology, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt. | ||
| 3Department of physiology, Faculty of Medicine, Assiut University | ||
| Abstract | ||
| Purpose: Primary open-angle glaucoma has been identified as the most common type of glaucoma. Elevated intraocular pressure, advanced age, positive family history, and African ancestry are well-known risk factors for primary open-angle glaucoma. Vitamin D is a known vital contributor to health. Thus, this present study aimed to clarify the neurophysiological role of vitamin D deficiency in primary open-angle glaucoma and to examine the correlation between vitamin D deficiency and the structural changes associated with primary open-angle glaucoma. Patients and Methods: All patients participating in this study underwent the best visual acuity examination. In addition, intraocular pressure, optical coherence tomography, and visual evoked potentials were measured. Results: As per our findings, it was determined that vitamin D negatively correlated with intraocular pressure in patients less than 45 years of age (r-value: −0.803; p-value: 0.002). Vitamin D also negatively correlated with age when optical coherence tomography was >94 µm (r-value: −0.526; p-value: 0.044). Vitamin D negatively correlated with intraocular pressure when visual evoked potential latency was Conclusion: We can conclude that vitamin D has an ameliorating effect on intraocular pressure when optic nerve conduction velocity is normal, but once optic nerve function deteriorates, the vitamin D effect decreases. | ||
| Keywords | ||
| Primary open-angle glaucoma; Vitamin D; IOP; OCT; VEP | ||
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