The Toxic Effect of Bisphenol A on Albino Rat Testicles and the Possible Protective Value of Vitamin E and Melatonin
Rashad, S., Ahmed, S., El-Sayed, M., Ahmed, D. (2021). The Toxic Effect of Bisphenol A on Albino Rat Testicles and the Possible Protective Value of Vitamin E and Melatonin. EKB Journal Management System, 9(2), 1-12. doi: 10.21608/esctj.2021.63294.1001
Somaia Rashad; Samia Ahmed; Mahmoud El-Sayed; Dalia Ahmed. "The Toxic Effect of Bisphenol A on Albino Rat Testicles and the Possible Protective Value of Vitamin E and Melatonin". EKB Journal Management System, 9, 2, 2021, 1-12. doi: 10.21608/esctj.2021.63294.1001
Rashad, S., Ahmed, S., El-Sayed, M., Ahmed, D. (2021). 'The Toxic Effect of Bisphenol A on Albino Rat Testicles and the Possible Protective Value of Vitamin E and Melatonin', EKB Journal Management System, 9(2), pp. 1-12. doi: 10.21608/esctj.2021.63294.1001
Rashad, S., Ahmed, S., El-Sayed, M., Ahmed, D. The Toxic Effect of Bisphenol A on Albino Rat Testicles and the Possible Protective Value of Vitamin E and Melatonin. EKB Journal Management System, 2021; 9(2): 1-12. doi: 10.21608/esctj.2021.63294.1001

The Toxic Effect of Bisphenol A on Albino Rat Testicles and the Possible Protective Value of Vitamin E and Melatonin

Egyptian Society of Clinical Toxicology Journal
Article 1, Volume 9, Issue 2, December 2021, Pages 1-12    PDF (830.4 K)
Document Type: Original Article
DOI: 10.21608/esctj.2021.63294.1001
Authors
Somaia Rashad1; Samia Ahmed1; Mahmoud El-Sayed1; Dalia Ahmed* 2
1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University.
2Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University
Abstract
Objectives. To study bisphenol A (BPA) effect on testicular functions in adult male rats using histopathology, and biochemical assays and to investigate vitamin E and melatonin role on BPA-induced testicular toxicity in male rats.
Methods. Adult male Sprague Dawley rats were divided into six groups (n=7) including negative control group, vehicle control group (0.2 mL of corn oil), BPA group (50 mg/kg), BPA(50 mg/kg) +vitamin E (100 mg/kg) group, BPA(50 mg/kg) + melatonin (10 mg/kg) group, BPA(50 mg/kg) +vitamin E (100 mg/kg) + melatonin (10 mg/kg) group. All medications were given 3 days a week for 3 weeks by intraperitoneal injection except vitamin E were given orally by a gavage needle. Laboratory investigations (testosterone level &sperm parameters), glutathione peroxidase (GPX) activity, and histopathological examination of testis were done.
Results. The BPA-treated rats showed a significant reduction in the reproductive function parameters. Furthermore, BPA induced testicular oxidative stress by decreasing GPX activity and induced significant histopathological testicular changes. Co-treatment with vitamin E and melatonin protected against these alterations.
Conclusion. Findings from the present study confirmed that BPA caused testicular dysfunction which may be due to BPA-induced oxidative stress and showed that vitamin E and melatonin antioxidants may have a protective role on the reproductive toxicity induced by BPA in male rats.
Keywords
bisphenol A; reproductive dysfunction; oxidative stress; vitamin E; melatonin
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