A Review of Chalcones: Synthesis, Reactions, and Biological Importance

Mukhtar, Shorouk S.; Morsy, Nesrin M.; Hassan, Ashraf S.; Hafez, Taghrid S.; Hassaneen, Hamdi M.; Saleh, Fatma M.

doi:10.21608/ejchem.2022.112735.5125

	A Review of Chalcones: Synthesis, Reactions, and Biological Importance
Egyptian Journal of Chemistry
Article 35, Volume 65, Issue 8, August 2022, Page 379-395 PDF (483 K)
Document Type: Review Articles
DOI: 10.21608/ejchem.2022.112735.5125
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Authors
Shorouk S. Mukhtar ¹; Nesrin M. Morsy ²; Ashraf S. Hassan ³; Taghrid S. Hafez ⁴; Hamdi M. Hassaneen⁵; Fatma M. Saleh⁵
¹Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Dokki 12622, Egypt
²Organometallic and Organometalloid Chemistry Department,National Research Centre
³Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt
⁴Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622 Cairo, Egypt
⁵Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
Abstract
Chalcones are considered an important scaffold in organic compounds. Many of their derivatives have a lot of applications. Therefore, this review was covered some synthesis methods of chalcones such as Claisen-Schmidt’s condensation, coupling reaction, continuous-flow deuteration reaction, and other reactions. Also, some reactions were discussed such as the synthesis of seven, six, and five-membered ring heterocyclic compounds. Moreover, some of their biological applications were mentioned like antimicrobial, anticancer, anti-inflammatory, antioxidants, and others with some details.
Keywords
Chalcones; Synthesis; Reactions; Biological applications


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