Comparative Study of The Effect of Topical Minoxidil 5% Versus Combined Fractional CO2 Laser and Topical Minoxidil 5% in Treatment of Male Androgenetic Alopecia
Rashed, M., Sharaf, L., Ghanem, B. (2022). Comparative Study of The Effect of Topical Minoxidil 5% Versus Combined Fractional CO2 Laser and Topical Minoxidil 5% in Treatment of Male Androgenetic Alopecia. EKB Journal Management System, 86(1), 700-707. doi: 10.21608/ejhm.2022.215574
Mai Ibrahim Abd El-Motlib Rashed; Leila Sharaf; Bothaina Mahrous Ghanem. "Comparative Study of The Effect of Topical Minoxidil 5% Versus Combined Fractional CO2 Laser and Topical Minoxidil 5% in Treatment of Male Androgenetic Alopecia". EKB Journal Management System, 86, 1, 2022, 700-707. doi: 10.21608/ejhm.2022.215574
Rashed, M., Sharaf, L., Ghanem, B. (2022). 'Comparative Study of The Effect of Topical Minoxidil 5% Versus Combined Fractional CO2 Laser and Topical Minoxidil 5% in Treatment of Male Androgenetic Alopecia', EKB Journal Management System, 86(1), pp. 700-707. doi: 10.21608/ejhm.2022.215574
Rashed, M., Sharaf, L., Ghanem, B. Comparative Study of The Effect of Topical Minoxidil 5% Versus Combined Fractional CO2 Laser and Topical Minoxidil 5% in Treatment of Male Androgenetic Alopecia. EKB Journal Management System, 2022; 86(1): 700-707. doi: 10.21608/ejhm.2022.215574

Comparative Study of The Effect of Topical Minoxidil 5% Versus Combined Fractional CO2 Laser and Topical Minoxidil 5% in Treatment of Male Androgenetic Alopecia

The Egyptian Journal of Hospital Medicine
Article 113, Volume 86, Issue 1, January 2022, Page 700-707  XML PDF (199.57 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2022.215574
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Authors
Mai Ibrahim Abd El-Motlib Rashed email ; Leila Sharaf; Bothaina Mahrous Ghanem
Abstract
Background: Male androgenetic alopecia (MAA) is the most common hair problem among men. Androgenetic alopecia (AGA) is a non-scarring progressive miniaturization of the hair follicle with a usual characteristic pattern of distribution in genetically predisposed men and women.
Objective: To compare between the efficacy of topical minoxidil 5% alone and combined topical minoxidil 5% and fractional laser in treatment of male androgenic alopecia and detection of any side effects occurring with each line of treatment.
Patients and Methods: This prospective randomized comparative controlled study was conducted for one year on 40 patients with male androgenic alopecia attending to out Patient Clinic of Dermatology, Andrology and STDs Department, Mansoura University Hospitals. Patients were classified into two groups: Group A received minoxidil alone (minoxidil group) and group B where patients received minoxidil plus fractional CO2 laser.
Results: In group A and B, there was a statistically significant improvement between the clinical assessment scale at baseline and after 1 month (p < 0.001). Also, there was a statistically significant improvement between the clinical assessment scale after 1 month and after 3 months (p=0.002). In group A, there was a statistically significant improvement between the clinical assessment scale at baseline and after 1 month, however, there was no statistically significant improvement between the clinical assessment scale after 1 month and after 3 months. In group B, there was a statistically significant improvement between the clinical assessment scale at baseline and after 1 month, however, also, there was a statistically significant improvement between the clinical assessment scale after 1 month and after 3 months.
Conclusion: Our study revealed the superiority of combination therapy, using a fractional laser and 5% minoxidil, over 5% minoxidil alone, for the treatment of male AGA, with no serious adverse effects of treatment identified.
 
Keywords
Androgenetic alopecia; Fractional CO2 laser; Topical minoxidil 5%
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