Synthesis and Characterization of Novel Isoxazolidine-Thiosemicarbazone Hybrid Derivatives as Precursor of Unnatural Amino acids | ||
| Egyptian Journal of Chemistry | ||
| Article 42, Volume 65, Issue 9, September 2022, Pages 439-447 PDF (752.64 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.111980.5088 | ||
| Authors | ||
| snoussi mejdi1; Ameni Ghabi1; jihed brahmi2; Adel Kadri3; Kais Aouadi* 4 | ||
| 1University of Monastir | ||
| 2university of monastir | ||
| 3Faculty of Science of Sfax, Department of Chemistry, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia. | ||
| 4Department of Chemistry, College of Science, Qassim University, buraidah | ||
| Abstract | ||
| Novel sixteen enantiopure isoxazolidine-(thio)semicarbazone hybrid derivatives were synthesized by condensation of isoxazolidines based on benzaldehyde derivatives with (thio)semicarbazide in good yield. The analysis of the 1D NMR and NOESY spectra of all compounds unambiguously confirms the E-stereochemistry of the synthesized (thio)semicarbazones. | ||
| Keywords | ||
| isoxazolidine; semicarbazone; thiosemicarbazone; enantiopure; stereochemistry | ||
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