A Comparative Study of Psoriasis and Psoriasiform Dermatoses on Basis of Ki-67 Immunohistochemical Expression | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 138, Volume 86, Issue 1, January 2022, Pages 840-844 PDF (769.46 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2022.218029 | ||
| Authors | ||
| Hajir Fathalla Farag Abdelsalam* ; Mai Ahmad Gobran; Mai Mohamed Abdelwahab; Hesham Radwan Abdelaziz | ||
| Abstract | ||
| Introduction: The prototypical psoriasiform tissue pattern is psoriasis, both clinically and histopathologically. However, it should be distinguished from other psoriasiform dermatoses. Objective: This study aimed to determine the expression of Ki-67 immunohistochemically in psoriasis and psoriasiform dermatoses for diagnostic reasons. Material and Methods: Between January 2020 and January 2021, a cross-sectional study was conducted on the paraffin blocks of 22 psoriasis and 22 psoriasiform dermatoses patients. Four-micron sections were cut from formalin-fixed paraffin-embedded tissue from each biopsy specimen. Hematoxylin and eosin staining was used to colour the initial sections. Additionally, Ki-67 immunohistochemistry was performed. Results: Mean value of KI-67 expression was highly significant in psoriasis (94.4 ± 11) versus (21.1 ± 5.7) than in psoriasiform dermatoses (P value < 0.001). Conclusion: Ki-67 expression was shown to be significantly elevated in psoriasis compared to the other types of dermatoses studied. | ||
| Keywords | ||
| Immunohistochemistry; Psoriasis; Dermatoses; Ki-67 | ||
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