Relation Between Serum 25 Hydroxy Vitamin D Levels and Severity of Atopic Dermatitis
Murshidi, I., Ghanem, A., Shawky, N., said abdelshafy, A. (2024). Relation Between Serum 25 Hydroxy Vitamin D Levels and Severity of Atopic Dermatitis. EKB Journal Management System, 30(1.3), 381-389. doi: 10.21608/zumj.2022.98957.2378
Injy Fakhr El Din Murshidi; Afaf Ghanem; Nagwa Mohammed Shawky; Ahmad said abdelshafy. "Relation Between Serum 25 Hydroxy Vitamin D Levels and Severity of Atopic Dermatitis". EKB Journal Management System, 30, 1.3, 2024, 381-389. doi: 10.21608/zumj.2022.98957.2378
Murshidi, I., Ghanem, A., Shawky, N., said abdelshafy, A. (2024). 'Relation Between Serum 25 Hydroxy Vitamin D Levels and Severity of Atopic Dermatitis', EKB Journal Management System, 30(1.3), pp. 381-389. doi: 10.21608/zumj.2022.98957.2378
Murshidi, I., Ghanem, A., Shawky, N., said abdelshafy, A. Relation Between Serum 25 Hydroxy Vitamin D Levels and Severity of Atopic Dermatitis. EKB Journal Management System, 2024; 30(1.3): 381-389. doi: 10.21608/zumj.2022.98957.2378

Relation Between Serum 25 Hydroxy Vitamin D Levels and Severity of Atopic Dermatitis

Zagazig University Medical Journal
Article 921, Volume 30, Issue 1.3, March and April 2024, Page 381-389  XML PDF (1.06 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2022.98957.2378
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Authors
Injy Fakhr El Din Murshidi email 1; Afaf Ghanem2; Nagwa Mohammed Shawky3; Ahmad said abdelshafy2
1Department of dermatology and venereology, New Cairo Hospital, New Cairo, Cairo, Egypt
2Dermatology, Venereology and Andrology department, Faculty of Medicine, Zagazig University, Egypt.
3clinical pathology department,faculty of medicine,zagazig university
Abstract
Background & Aim: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. The ethiopathogenesis of AD is complicated, but is mainly due to a multifactorial interplay between the presence of a defective skin barrier, immunological dysregulation and environmental factors. Vitamin D is a fat-soluble vitamin synthesized in the skin. Recently, there have been several reports that low vitamin D plays a role in the pathogenesis of many conditions including AD. Adaptive and innate immune systems are both regulated by Vitamin D. Consequently, an obvious link between Vitamin D and allergic diseases was constantly a matter of investigation and research. Therefore, the aim of this study was to determine if there was a relationship between Vitamin D deficiency and the severity of Atopic Dermatitis.
Patients and Methods: The study included 36 patients suffering from mild, moderate, and severe atopic dermatitis assessed according to SCORAD index and 36 apparently healthy subjects as a control group. The study was conducted in the Dermatology, Venereology and Andrology outpatients’ clinic at Zagazig University hospitals from November 2018 to April 2019 to avoid seasonal variations in Vitamin D levels.
Results: Our study showed that 81.8% of the severe AD cases had deficient vitamin D levels compared to 23.1% and 50% among mild and moderate AD cases respectively, with a statistically significant difference among cases.
Conclusion: Vitamin D deficiency is a contributing factor for the worsening of AD in the form of a high SCORAD index.
Keywords
Atopic dermatitis; Vitamin D deficiency; SCORAD
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