Survival assessment and function of heterotopic autotransplanted thyroid tissue after total thyroide
El Hadad, L., Mohsen, A., El Sanadeky, M., Mahran, K. (2020). Survival assessment and function of heterotopic autotransplanted thyroid tissue after total thyroide. EKB Journal Management System, 31(2), 142-145. doi: 10.21608/mjmr.2022.220852
Lamis H. Mohamed El Hadad; Amr A. Mohsen; Mostafa N. El Sanadeky; Khaled Mahran. "Survival assessment and function of heterotopic autotransplanted thyroid tissue after total thyroide". EKB Journal Management System, 31, 2, 2020, 142-145. doi: 10.21608/mjmr.2022.220852
El Hadad, L., Mohsen, A., El Sanadeky, M., Mahran, K. (2020). 'Survival assessment and function of heterotopic autotransplanted thyroid tissue after total thyroide', EKB Journal Management System, 31(2), pp. 142-145. doi: 10.21608/mjmr.2022.220852
El Hadad, L., Mohsen, A., El Sanadeky, M., Mahran, K. Survival assessment and function of heterotopic autotransplanted thyroid tissue after total thyroide. EKB Journal Management System, 2020; 31(2): 142-145. doi: 10.21608/mjmr.2022.220852

Survival assessment and function of heterotopic autotransplanted thyroid tissue after total thyroide

Minia Journal of Medical Research
Volume 31, Issue 2, April 2020, Page 142-145  XML PDF (392.79 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.220852
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Authors
Lamis H. Mohamed El Hadad1; Amr A. Mohsen2; Mostafa N. El Sanadeky1; Khaled Mahran1
1Department of General Surgery; Faculty of medicine; Minia university; Egypt
2Department of General and Laparoscopic Surgery; Faculty of medicine; Cairo University; Egypt
Abstract
Background/Objective: Limited animal and human studies have shown function, albeit inadequate, 
of implanted thyroid tissue in muscles. This work aimed to ascertain results in a larger number of 
patients, finding practical method for implantation, studying the effect of changing weight of implant 
and effect of passage of time on its function. Methods: Forty patients had total thyroidectomy for 
simple multinodular goiters. A piece of the excised gland was finely minced, mixed with saline as 
emulsion, and injected in thigh muscles. Twelve patients had 5-g implants, while 28 patients had 10-g 
implants. Four parameters were studied at 2 months, 6 months, and 12 months: technetium isotope 
uptake by the implant; thyroid stimulating hormone (TSH); free T3 (FT3); and free T4 (FT4). 
Results: All autotransplanted thyroid tissue survived and functioned. After 12 months, mean values (_ 
standard deviation) of isotope uptake, TSH, FT3, and FT4 of the 5-g implants were 0.44 _ 0.16%, 
27.74 _ 30.4 UI/mL, 3.07 _ 1.10 pg/mL, and 1.01_0.3 ng/dL, respectively. Those for the 10 g 
implants were 0.71_0.20%, 22.78_19.7 UI/mL, 3.92_1.2 pg/mL, and 1.05 _ 0.3 ng/dL, respectively. 
Ten-gram implants showed significantly higher isotope uptake than 5-g. TSH, FT3, and FT4 
significantly improved over the period of 1 year. Conclusion: Injection of thyroid tissue suspension is 
a simple method for thyroid autotransplantation. TSH was elevated in the majority to maintain normal 
or near normal thyroid hormones. Ten-gram implants showed higher isotope uptake than 5-g, 
although this difference was not reflected by thyroid hormone profile. The implant seemed to function 
better with the passage of time from 2 months to 12 months.

Keywords
multinodular goiter; thyroid autotransplantation; thyroidectomy
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